| Autor: |
Sarper N; Department of Pediatrics, Division of Hematology †Department of Pathology, Kocaeli University, Kocaeli, Turkey., Gelen SA, Zengin E, Demirsoy U, Erçin C |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2015 Aug; Vol. 37 (6), pp. 486-7. |
| DOI: |
10.1097/MPH.0000000000000363 |
| Abstrakt: |
A 9.5-year-old girl with malaise, fever, massive hepatosplenomegaly, anemia, leukocytosis (37.9 × 10(9)/L), monocytosis (1.48 × 10(9)/L), and thrombocytopenia is presented. Hemoglobin F was increased (18%). Bone marrow erythroid/myeloid ratio was 40/1 with 7% myeloblast and 5% monocyte suggesting erythroleukemia or juvenile myelomonocytic leukemia (JMML). The patient had a fulminant course with respiratory compromise and died in 2 weeks before heterozygous somatic mutation in the PTPN11 gene was shown. JMML must be considered also in the patients older than 6 years. A cytopenic phase may precede JMML. Leucocytosis may be transient and there may be predominance of erythroid precursors in the bone marrow. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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