| Autor: |
Volpina OM, Volkova TD, Medvinskaya NI, Kamynina AV, Zaporozhskaya YV, Aleksandrova IJ, Koroev DO, Samokhin AN, Nesterova IV, Deygin VI, Bobkova NV |
| Jazyk: |
ruština |
| Zdroj: |
Bioorganicheskaia khimiia [Bioorg Khim] 2015 Mar-Apr; Vol. 41 (2), pp. 145-53. |
| DOI: |
10.1134/s1068162015020168 |
| Abstrakt: |
The prion protein is considered as one of the membrane targets of neurotoxic beta-amyloid during Alzheimer's disease development. We have chosen and synthesized 17-33, 23-33, 95-110 and 101-115 prion fragments involved in beta-amyloid binding. The effect of immunization with the peptides on the features of Alzheimer's disease was investigated in animals with an experimentally induced form of the disease. It was shown that immunization either with peptide 17-33 or with protein conjugates of peptides 23-33 and 101-115 increases the level of brain beta-amyloid and improves morfofunctional state of the brain. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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