MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells.

Autor:	Ohnmacht C; Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France., Park JH; Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France., Cording S; Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France., Wing JB; Laboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan., Atarashi K; RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Kanagawa 230-0045, Japan. PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan., Obata Y; The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan., Gaboriau-Routhiau V; INSERM, U1163, Laboratory of Intestinal Immunity, Paris, France. Université Paris Descartes-Sorbonne Paris Cité and Institut Imagine, Paris, France. INRA Micalis UMR1319, Jouy-en-Josas, France., Marques R; Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France., Dulauroy S; Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France., Fedoseeva M; Center of Allergy and Environment (ZAUM), Technische Universität and Helmholtz Zentrum München, Munich, Germany., Busslinger M; Research Institute of Molecular Pathology, Vienna Biocenter, 1030 Vienna, Austria., Cerf-Bensussan N; INSERM, U1163, Laboratory of Intestinal Immunity, Paris, France. Université Paris Descartes-Sorbonne Paris Cité and Institut Imagine, Paris, France., Boneca IG; Institut Pasteur, Biology and Genetics of Bacterial Cell Wall, 75724 Paris, France. INSERM, Groupe Avenir, 75015 Paris, France., Voehringer D; Department of Infection Biology at the Institute of Clinical Microbiology, Immunology and Hygiene, University Clinic Erlangen and Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany., Hase K; The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan., Honda K; RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Kanagawa 230-0045, Japan. CREST, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan., Sakaguchi S; Laboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Suita 565-0871, Japan. Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan., Eberl G; Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France. gerard.eberl@pasteur.fr.
Jazyk:	angličtina
Zdroj:	Science (New York, N.Y.) [Science] 2015 Aug 28; Vol. 349 (6251), pp. 989-93. Date of Electronic Publication: 2015 Jul 09.
DOI:	10.1126/science.aac4263
Abstrakt:	Changes to the symbiotic microbiota early in life, or the absence of it, can lead to exacerbated type 2 immunity and allergic inflammations. Although it is unclear how the microbiota regulates type 2 immunity, it is a strong inducer of proinflammatory T helper 17 (T(H)17) cells and regulatory T cells (T(regs)) in the intestine. Here, we report that microbiota-induced T(regs) express the nuclear hormone receptor RORγt and differentiate along a pathway that also leads to T(H)17 cells. In the absence of RORγt(+) T(regs), T(H)2-driven defense against helminths is more efficient, whereas T(H)2-associated pathology is exacerbated. Thus, the microbiota regulates type 2 responses through the induction of type 3 RORγt(+) T(regs) and T(H)17 cells and acts as a key factor in balancing immune responses at mucosal surfaces. (Copyright © 2015, American Association for the Advancement of Science.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu PDF