Enhancement of the antibiotic activity of aminoglycosides by extracts from Anadenanthera colubrine (Vell.) Brenan var. cebil against multi-drug resistant bacteria.

Autor:	Barreto HM; a Laboratory of Research in Microbiology, Federal University of Piauí , Teresina , PI , Brazil., Coelho KM; a Laboratory of Research in Microbiology, Federal University of Piauí , Teresina , PI , Brazil., Ferreira JH; a Laboratory of Research in Microbiology, Federal University of Piauí , Teresina , PI , Brazil., Dos Santos BH; b Laboratory of Clinical Microbiology, Federal University of Paraiba , João Pessoa , PB , Brazil., de Abreu AP; c Laboratory of Microbiology, Faculty of Higher Education of Floriano , Floriano , PI , Brazil., Coutinho HD; d Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, Regional University of Cariri , Crato , CE , Brazil., da Silva RA; e Laboratory of Natural Products, Federal University of Piauí , Teresina , PI , Brazil., de Sousa TO; e Laboratory of Natural Products, Federal University of Piauí , Teresina , PI , Brazil., Citó AM; e Laboratory of Natural Products, Federal University of Piauí , Teresina , PI , Brazil., Lopes JA; e Laboratory of Natural Products, Federal University of Piauí , Teresina , PI , Brazil.
Jazyk:	angličtina
Zdroj:	Natural product research [Nat Prod Res] 2016 Jun; Vol. 30 (11), pp. 1289-92. Date of Electronic Publication: 2015 Jul 09.
DOI:	10.1080/14786419.2015.1049177
Abstrakt:	The aim of this work was to evaluate the antimicrobial activity of ethanol (EEAC) and hexane (HFAC) extracts from the stem bark of Anadenanthera colubrina (Vell.) Brenan var. cebil alone or in combination with aminoglycosides against multi-drug resistant (MDR) bacteria. Minimal inhibitory concentrations (MICs) of the extracts were determined by using microdilution assay. For the evaluation of extracts as modulators of antibiotic resistance, MICs of neomycin and amikacin were determined in presence or absence of each compound at sub-inhibitory concentrations. Both EEAC and HFAC did not show antimicrobial activity against MDR strains tested. However, the addition of EEAC and HFAC enhanced the activity of neomycin and amikacin against Staphylococcus aureus SA10 strain. When the natural products were replaced by chlorpromazine, the same effect was observed. Anadenanthera colubrine var. cebil may be a source of phytochemicals able to potentiate the aminoglycoside activity against MDR S. aureus by the inhibition of efflux pump.
Databáze:	MEDLINE
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