Dyslipidemia in young patients with type 1 diabetes mellitus.

Autor:	Homma TK; Pediatric Endocrinology Unit, Pediatrics Department, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil., Endo CM; School of Medicine, Santa Casa São Paulo, São Paulo, SP, Brazil., Saruhashi T; School of Medicine, Santa Casa São Paulo, São Paulo, SP, Brazil., Mori AP; School of Medicine, Santa Casa São Paulo, São Paulo, SP, Brazil., Noronha RM; Pediatrics Department, ISCMSP, São Paulo, SP, Brazil., Monte O; Pediatric Endocrinology Unit, Pediatrics Department, ISCMSP., Calliari LE; Pediatric Endocrinology Unit, Pediatrics Department, ISCMSP.
Jazyk:	angličtina
Zdroj:	Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2015 Jun; Vol. 59 (3), pp. 215-9.
DOI:	10.1590/2359-3997000000040
Abstrakt:	Objective: The association between type 1 diabetes mellitus (T1D) and dyslipidemia (DLP) increases the risk of cardiovascular disease (CVD). The aim of this study was to evaluate the presence of dyslipidemia in young T1D patients. Materials and Methods: The study design was cross-sectional and descriptive. We reviewed medical records of T1D patients followed at an endocrinology service, from 1998-2012. Data Collected: gender, actual age and age at diagnosis, duration of T1D since diagnosis, body mass index (BMI), pubertal stage, glycemic control (GC) determined by glycated hemoglobin (HbA1c), total cholesterol (TC), HDL, LDL, triglycerides (TG). To analyze lipid profile and metabolic control, we used the Brazilian Society of Diabetes Guidelines. Results: Were included 239 T1D patients, 136 (56.9%) females; mean ± SD: actual age 15.7 ± 5.0 years and at T1D diagnosis 7.3 ± 3.9; T1D duration 10.6 ± 6.4 years, 86.6% puberty, 15.1% overweight. The prevalence of DLP was 72.5%, 63.3% females, 86.6% puberty, mean ± SD: actual age 15.4 ± 4.8 years and at T1D diagnosis 7.2 ± 4.1 years, duration of T1D 10.7 ± 6.1 years. We found high-CT in 56.7%, low-HDL = 21.7%, high LDL = 44.0%, high-TG = 11.8%. Between females with DLP, 83.5% was in puberty. We find correlation between the presence of DLP, a poor GC and BMC. Conclusion: We found a high prevalence of DLP in young patients with T1D, particularly in puberty females. Programs targeting the prevention of dyslipidemia should be adopted, especially for this group, in order to prevent/delay chronic complications and cardiovascular disease.
Databáze:	MEDLINE
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