BRAF gene: From human cancers to developmental syndromes.

Autor:	Hussain MR; Faculty of Genetic Medicine, King Abdulaziz University, Jeddah, Saudi Arabia ; CAS-Institute of microbiology, University of Chinese Academy of Sciences, Beijing, China., Baig M; Faculty of Medicine, King Abdulaziz University, Rabigh Branch, Saudi Arabia., Mohamoud HS; Human Genetics Research Centre, Division of Biomedical Sciences (BMS), St. George's University of London (SGUL), London, UK., Ulhaq Z; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan., Hoessli DC; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan., Khogeer GS; Department of Biology, Genomics and Biotechnology Section, King Abdulaziz University, Jeddah, Saudi Arabia., Al-Sayed RR; Department of Biology, Genomics and Biotechnology Section, King Abdulaziz University, Jeddah, Saudi Arabia., Al-Aama JY; Faculty of Genetic Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Saudi journal of biological sciences [Saudi J Biol Sci] 2015 Jul; Vol. 22 (4), pp. 359-73. Date of Electronic Publication: 2014 Oct 23.
DOI:	10.1016/j.sjbs.2014.10.002
Abstrakt:	The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade in human cancers and RAS/MAPK syndromes, and focuses the molecular basis and clinical genetics of BRAF to better understand its parallel involvement in both tumourigenesis and RAS/MAPK syndromes-Noonan syndrome, cardio-facio-cutaneous syndrome and LEOPARD syndrome.
Databáze:	MEDLINE
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