Olfactory and gustatory dysfunction in Myasthenia gravis: A study in Turkish patients.

Autor: Tekeli H; GATA Haydarpasa Training Hospital, Department of Neurology, İstanbul, Turkey., Senol MG; GATA Haydarpasa Training Hospital, Department of Neurology, İstanbul, Turkey., Altundag A; Istanbul Surgery Hospital, Department of Otorhinolaryngology, İstanbul, Turkey., Yalcınkaya E; Koru Hospitals, Department of Otorhinolaryngology, Ankara, Turkey., Kendirli MT; GATA Haydarpasa Training Hospital, Department of Neurology, İstanbul, Turkey., Yaşar H; Ankara Mevki Military Hospital, Department of Neurology, Ankara, Turkey. Electronic address: yasarhalit@gmail.com., Salihoglu M; GATA Haydarpasa Training Hospital, Department of Otorhinolaryngology, İstanbul, Turkey., Saglam O; Kasımpasa Military Hospital, Department of Otorhinolaryngology, İstanbul, Turkey., Cayonu M; Amasya Training And Research Hospital, Department of Otorhinolaryngology, Amasya, Turkey., Cesmeci E; Diyarbakır Military Hospital, Department of Otorhinolaryngology, Diyarbakır, Turkey., Hummel T; Technical University of Dresden, Department of Otorhinolaryngology, Smell and Taste Clinic, Dresden, Germany.
Jazyk: angličtina
Zdroj: Journal of the neurological sciences [J Neurol Sci] 2015 Sep 15; Vol. 356 (1-2), pp. 188-92. Date of Electronic Publication: 2015 Jun 27.
DOI: 10.1016/j.jns.2015.06.054
Abstrakt: Objective: Myasthenia gravis (MG) is commonly viewed as a muscle disorder. Less is known about neurosensory function and dysfunction in MG. We aim to evaluate olfactory and gustatory behavior in Turkish patients with MG, and compare these results with age and sex-matched healthy controls.
Material/methods: 30 individuals with MG, and 30 healthy volunteers were studied. Olfactory function was studied with the Sniffin' sticks test. Taste strip test was used for studying taste function. The t-test was used for analyzing continuous variables, and the chi-square test for categorical data. Clinical staging and medication status were included in a model analyzed using analysis of variances.
Results: MG patients showed significantly lower olfactory (p<0.001) and gustatory scores (p<0.001) than the healthy controls. In addition, olfactory loss correlated with the severity of the disease. Medications for MG did not influence these results.
Conclusion: This study replicates the olfactory dysfunction found elsewhere in MG. Further, gustatory dysfunction, an activity unrelated to muscle strength, was also unveiled. Medications used for treating MG must not be blamed for the chemosensory dysfunction found in this neurological disorder.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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