Electrical Stimulation of Human Mesenchymal Stem Cells on Conductive Nanofibers Enhances their Differentiation toward Osteogenic Outcomes.

Autor: Hardy JG; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA.; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Villancio-Wolter MK; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA., Sukhavasi RC; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA., Mouser DJ; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA., Aguilar D Jr; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA., Geissler SA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA.; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA., Kaplan DL; Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA., Schmidt CE; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA.; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Jazyk: angličtina
Zdroj: Macromolecular rapid communications [Macromol Rapid Commun] 2015 Nov; Vol. 36 (21), pp. 1884-1890. Date of Electronic Publication: 2015 Jul 06.
DOI: 10.1002/marc.201500233
Abstrakt: Tissue scaffolds allowing the behavior of the cells that reside within them to be controlled are of particular interest for tissue engineering. Herein, the preparation of conductive fiber-based bone tissue scaffolds (nonwoven mats of electrospun polycaprolactone with an interpenetrating network of polypyrrole and polystyrenesulfonate) is described that enable the electrical stimulation of human mesenchymal stem cells to enhance their differentiation toward osteogenic outcomes.
(© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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