| Autor: |
Clement LL; Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark. thpou@chem.au.dk., Tsakos M, Schaffert ES, Scavenius C, Enghild JJ, Poulsen TB |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2015 Aug 11; Vol. 51 (62), pp. 12427-30. |
| DOI: |
10.1039/c5cc04500b |
| Abstrakt: |
We demonstrate that a unique class-defining functionality (mc-APD) found in macrocyclic natural products with potent anti-cancer activity, imparts these compounds with electrophilic reactivity. The mc-APD group represents an interesting structural hybrid between canonical biologically relevant Michael-acceptors. Further, a novel thiol-elimination method for preparation of the mc-APD group is outlined. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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