Sexually dimorphic innate immunological responses of pre-pubertal Brahman cattle following an intravenous lipopolysaccharide challenge.

Autor: Carroll JA; USDA ARS Livestock Issues Research Unit, Lubbock, TX 79403, USA. Electronic address: jeff.carroll@ars.usda.gov., Burdick Sanchez NC; USDA ARS Livestock Issues Research Unit, Lubbock, TX 79403, USA; Department of Animal Science, Texas AgriLife Research, Texas A&M University System, College Station, TX 77843, USA., Hulbert LE; USDA ARS Livestock Issues Research Unit, Lubbock, TX 79403, USA; Department of Animal and Food Sciences, Texas Tech University, Lubbock, TX 79409, USA., Ballou MA; Department of Animal and Food Sciences, Texas Tech University, Lubbock, TX 79409, USA., Dailey JW; USDA ARS Livestock Issues Research Unit, Lubbock, TX 79403, USA., Caldwell LC; Department of Animal Science, Texas AgriLife Research, Texas A&M University System, College Station, TX 77843, USA., Vann RC; Brown Loam Branch Experiment Station, Mississippi State University, Raymond, MS 39154, USA., Welsh TH Jr; Department of Animal Science, Texas AgriLife Research, Texas A&M University System, College Station, TX 77843, USA., Randel RD; Texas AgriLife Research Center, Overton, TX 75684, USA.
Jazyk: angličtina
Zdroj: Veterinary immunology and immunopathology [Vet Immunol Immunopathol] 2015 Aug 15; Vol. 166 (3-4), pp. 108-15. Date of Electronic Publication: 2015 Jun 23.
DOI: 10.1016/j.vetimm.2015.06.009
Abstrakt: This study was designed to characterize potential sexually dimorphic immunological responses following a lipopolysaccharide (LPS) challenge in beef cattle. Six female (heifers) and five male (bulls) Brahman calves (average age=253 ± 19.9 and 288 ± 47.9 days; average body weight=194 ± 11 kg and 247 ± 19 kg for heifers and bulls, respectively) were challenged with LPS (0.25 μg LPS/kg body weight). Following administration of LPS, all cattle displayed increased sickness behavior beginning at 0.5h, with heifers on average displaying less sickness behavior than bulls. A febrile response was observed in all animals following LPS administration, with a maximum response observed from 4 to 5.5h. The average rectal temperature response was greater in heifers than bulls. In all cattle there were elevated serum concentrations of cortisol from 0.5 to 8h, TNF-α from 1 to 2.5h, IL-6 from 2 to 8h, and IFN-γ from 2.5 to 7h after LPS challenge. Additionally, serum concentrations of TNF-α were greater in heifers than bulls from 1.5 to 2h after the LPS challenge. Concentrations of IFN-γ were also greater on average in bulls than heifers. Leukopenia occurred from 1 to 8h, with a decreased neutrophil to lymphocyte ratio for the first 5h among all calves. These data demonstrate the existence of a sexually dimorphic acute-phase response in pre-pubertal Brahman calves. Specifically, heifers may have a more robust acute response to LPS challenge, even though bulls display more signs of sickness.
(Published by Elsevier B.V.)
Databáze: MEDLINE
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