Serum YKL-40/chitinase 3-like protein 1 level is an independent predictor of atherosclerosis development in patients with obstructive sleep apnea syndrome.

Autor:	Bakırcı EM; Department of Cardiology, Erzincan University Faculty of Medicine, Erzincan, Turkey. eftalka@yahoo.com., Ünver E; Department of Pulmonary Diseases, Erzincan University Faculty of Medicine, Erzincan, Turkey., Değirmenci H; Department of Cardiology, Erzincan University Faculty of Medicine, Erzincan, Turkey., Kıvanç T; Department of Pulmonary Diseases, Başkent University Faculty of Medicine, Konya, Turkey., Günay M; Department of Biochemistry, Erzincan University Faculty of Medicine, Erzincan, Turkey., Hamur H; Department of Cardiology, Erzincan University Faculty of Medicine, Erzincan, Turkey., Büyüklü M; Department of Cardiology, Erzincan University Faculty of Medicine, Erzincan, Turkey., Ceyhun G; Department of Cardiology, Erzincan University Faculty of Medicine, Erzincan, Turkey., Topal E; Department of Cardiology, Erzincan University Faculty of Medicine, Erzincan, Turkey., Çoban TA; Department of Biochemistry, Erzincan University Faculty of Medicine, Erzincan, Turkey.
Jazyk:	angličtina
Zdroj:	Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir [Turk Kardiyol Dern Ars] 2015 Jun; Vol. 43 (4), pp. 333-9.
DOI:	10.5543/tkda.2015.56805
Abstrakt:	Objective: The inflammatory process plays an important role in the development of cardiovascular complications in patients with obstructive sleep apnea syndrome (OSAS). YKL-40/chitinase 3-like protein 1 is a novel biomarker of systemic inflammation. This study aimed to investigate whether carotid intima-media thickness (CIMT), a useful marker for early atherosclerosis, is associated with serum YKL-40/chitinase 3-like protein 1 levels in patients with normotensive and nondiabetic OSAS. Methods: The study included 40 OSAS patients and 40 age- sex- and body mass index-matched healthy controls. Serum YKL-40 levels were detected by enzyme-linked immunosorbent assay. CIMT was measured by B-mode ultrasound. Results: The patients with OSAS had significantly increased CIMT and higher YKL-40 and high sensitivity C-reactive protein (hsCRP) levels than those of the controls. CIMT was strongly correlated with serum YKL-40 levels (r=0.694, p<0.001), hsCRP (r=0.622, p<0.001), age (r=0.525, p=0.001), and weakly correlated with apnea-hypopnea index (AHI) (r=0.365, p=0.021) and the percentage of recording time spent (PRTS) of oxygen saturation<90% (r=0.488, p=0.001). Moreover, it was detected that serum YKL-40 levels were strongly correlated with AHI (r=0.617, p<0.001), and weakly correlated with SaO2<90% of PRTS (r=0.394, p=0.012) and hsCRP (r=0.486, p=0.001). In multiple regression analyses, age and serum levels of YKL-40 and hsCRP were found to be independent predictors of CIMT. Conclusion: In patients with OSAS, CIMT was increased. This increase was associated with serum YKL-40 level. Increased serum level of YKL-40 may be an early predictor of atherosclerosis development in patients with OSAS.
Databáze:	MEDLINE
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