Use of magnetic resonance elastography for assessing liver functional reserve: A clinical study.

Autor:	Li B; Bin Li, Jie Min, Wei-Ren Liang, Guang-Qiang Zhang, Jian-Jun Wu, Kai Jin, Wei Huang, Cai-Yu Ying, Ming Chao, Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China., Min J; Bin Li, Jie Min, Wei-Ren Liang, Guang-Qiang Zhang, Jian-Jun Wu, Kai Jin, Wei Huang, Cai-Yu Ying, Ming Chao, Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China., Liang WR; Bin Li, Jie Min, Wei-Ren Liang, Guang-Qiang Zhang, Jian-Jun Wu, Kai Jin, Wei Huang, Cai-Yu Ying, Ming Chao, Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China., Zhang GQ; Bin Li, Jie Min, Wei-Ren Liang, Guang-Qiang Zhang, Jian-Jun Wu, Kai Jin, Wei Huang, Cai-Yu Ying, Ming Chao, Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China., Wu JJ; Bin Li, Jie Min, Wei-Ren Liang, Guang-Qiang Zhang, Jian-Jun Wu, Kai Jin, Wei Huang, Cai-Yu Ying, Ming Chao, Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China., Jin K; Bin Li, Jie Min, Wei-Ren Liang, Guang-Qiang Zhang, Jian-Jun Wu, Kai Jin, Wei Huang, Cai-Yu Ying, Ming Chao, Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China., Huang W; Bin Li, Jie Min, Wei-Ren Liang, Guang-Qiang Zhang, Jian-Jun Wu, Kai Jin, Wei Huang, Cai-Yu Ying, Ming Chao, Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China., Ying CY; Bin Li, Jie Min, Wei-Ren Liang, Guang-Qiang Zhang, Jian-Jun Wu, Kai Jin, Wei Huang, Cai-Yu Ying, Ming Chao, Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China., Chao M; Bin Li, Jie Min, Wei-Ren Liang, Guang-Qiang Zhang, Jian-Jun Wu, Kai Jin, Wei Huang, Cai-Yu Ying, Ming Chao, Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China.
Jazyk:	angličtina
Zdroj:	World journal of gastroenterology [World J Gastroenterol] 2015 Jun 28; Vol. 21 (24), pp. 7522-8.
DOI:	10.3748/wjg.v21.i24.7522
Abstrakt:	Aim: To investigate the value of magnetic resonance elastography (MRE) with regard to assessing liver functional reserve. Methods: Data from inpatients diagnosed with a liver tumor at an interventional radiology department from July 2013 to June 2014 were analyzed. A 3.0 Tesla magnetic resonance unit was used to scan 32 patients with confirmed diagnoses of hepatocellular carcinoma (HCC); an MRE sequence was added to the protocol, and the data were reconstructed and analyzed by two attending radiologists. Regions of interest were identified in different slices of the non-tumor liver parenchyma to measure average stiffness. In addition, the indocyanine green (ICG) test was performed no more than 1 wk before or after the magnetic resonance examination for all 32 patients; the ICG retention rate at 15 min (ICGR-15) and the ICG plasma clearance rate (ICG-K) were recorded. Correlational analyses were performed between the liver stiffness values and the ICGR-15 as well as between the liver stiffness values and the ICG-K. Results: Magnetic resonance imaging, including an MRE sequence and the ICG test, was performed successfully in all 32 enrolled patients. None of the patients developed complications. The mean ± SD of the elasticity values measured by the two attending radiologists were 4.7 ± 2.2 kPa and 4.7 ± 2.1 kPa, respectively. The average liver stiffness value of the non-tumor parenchyma measured using MRE in HCC patients was 4.7 ± 2.2 kPa. The average ICGR-15 was 0.089 ± 0.077, and the average ICG-K was 0.19 ± 0.07. We found that the liver stiffness value of the non-tumor parenchyma was significantly and positively related to the ICGR-15 (r = 0.746, P < 0.01) as well as significantly and negatively related to the ICG-K (r = -0.599, P < 0.01). The ICGR-15 was significantly and negatively related to the ICG-K (r = -0.852, P < 0.01). Conclusion: MRE is accurate and non-invasive; furthermore, it can be used to effectively assess the liver functional reserve of HCC patients.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu