Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression.

Autor: Jorgensen A; Psychiatric Centre Copenhagen (Rigshospitalet), Denmark.; Department of Neuroscience and Pharmacology, Laboratory of Neuropsychiatry, University of Copenhagen, Copenhagen, Denmark., Magnusson P; Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark., Hanson LG; Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark.; Biomedical Engineering, DTU Elektro, Technical University of Denmark, Lyngby, Denmark., Kirkegaard T; Psychiatric Centre Copenhagen (Rigshospitalet), Denmark., Benveniste H; Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY, USA.; Department of Radiology, Stony Brook Medicine, Stony Brook, NY, USA., Lee H; Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY, USA.; Department of Radiology, Stony Brook Medicine, Stony Brook, NY, USA., Svarer C; Neurobiology Research Unit, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark., Mikkelsen JD; Neurobiology Research Unit, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark., Fink-Jensen A; Psychiatric Centre Copenhagen (Rigshospitalet), Denmark.; Department of Neuroscience and Pharmacology, Laboratory of Neuropsychiatry, University of Copenhagen, Copenhagen, Denmark., Knudsen GM; Neurobiology Research Unit, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark., Paulson OB; Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark.; Neurobiology Research Unit, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark., Bolwig TG; Psychiatric Centre Copenhagen (Rigshospitalet), Denmark., Jorgensen MB; Psychiatric Centre Copenhagen (Rigshospitalet), Denmark.; Department of Neuroscience and Pharmacology, Laboratory of Neuropsychiatry, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Acta psychiatrica Scandinavica [Acta Psychiatr Scand] 2016 Feb; Vol. 133 (2), pp. 154-164. Date of Electronic Publication: 2015 Jul 03.
DOI: 10.1111/acps.12462
Abstrakt: Objective: To investigate the role of hippocampal plasticity in the antidepressant effect of electroconvulsive therapy (ECT).
Method: We used magnetic resonance (MR) imaging including diffusion tensor imaging (DTI) and proton MR spectroscopy ( 1 H-MRS) to investigate hippocampal volume, diffusivity, and metabolite changes in 19 patients receiving ECT for severe depression. Other regions of interest included the amygdala, dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex, and hypothalamus. Patients received a 3T MR scan before ECT (TP1), 1 week (TP2), and 4 weeks (TP3) after ECT.
Results: Hippocampal and amygdala volume increased significantly at TP2 and continued to be increased at TP3. DLPFC exhibited a transient volume reduction at TP2. DTI revealed a reduced anisotropy and diffusivity of the hippocampus at TP2. We found no significant post-ECT changes in brain metabolite concentrations, and we were unable to identify a spectral signature at ≈1.30 ppm previously suggested to reflect neurogenesis induced by ECT. None of the brain imaging measures correlated to the clinical response.
Conclusion: Our findings show that ECT causes a remodeling of brain structures involved in affective regulation, but due to their lack of correlation with the antidepressant effect, this remodeling does not appear to be directly underlying the antidepressant action of ECT.
(© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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