| Autor: |
Tureck LV; Polymorphism and Linkage Laboratory, Department of Genetics, Federal University of Paraná, Brazil., Leite N; Department of Physical Education, Federal University of Paraná, Brazil., Souza RL; Polymorphism and Linkage Laboratory, Department of Genetics, Federal University of Paraná, Brazil., da Silva Timossi L; Department of Physical Education, Federal University of Paraná, Brazil., Osiecki AC; Department of Physical Education, Federal University of Paraná, Brazil., Osiecki R; Department of Physical Education, Federal University of Paraná, Brazil., Alle LF; Polymorphism and Linkage Laboratory, Department of Genetics, Federal University of Paraná, Brazil. |
| Abstrakt: |
Adiponectin is an adipokine inversely correlated with obesity, which has beneficial effect on insulin resistance and lipid metabolism. Considering its potential as a therapeutic target in the metabolic disorder contexts, and in order to add knowledge in the area, our study evaluated the ADIPOQ 276G > T polymorphism effect on adiponectin levels, and on lipoproteins of clinical interest in a population sample composed of 211 healthy individuals. Significant effects were observed only among men: the carriers of heterozygous genotype (GT) showed high levels of adiponectin (p = 0.018), while the rare homozygous genotype (TT) gave its carriers a negative phenotype, represented by higher levels of low density lipoprotein cholesterol (LDL-C) (p = 0.004 and p = 0.005) and total cholesterol (TC) (p = 0.010 and p = 0.005) compared to carriers of other genotypes (GG and GT respectively), the independent effect of SNP on LDL-C and TC levels was confirmed by multiple regression analysis (p = 0.008 and p = 0.044). We found no evidence of correlation between circulating adiponectin levels and biochemical markers, which suggests, therefore, an SNP 276G > T independent effect on adiponectin levels and on lipoprotein metabolism in men enrolled in this study. |
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