Lowered paraoxonase 1 (PON1) activity is associated with increased cytokine levels in drug naïve first episode psychosis.

Autor: Brinholi FF; Graduation Program in Health Sciences, Universidade Estadual de Londrina, Londrina, PR, Brazil., Noto C; LiNC-Interdisciplinary Laboratory of Clinical Neuroscience, Universidade Federal de Sao Paulo, SP, Brazil; First Episode Psychosis Program, Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP), São Paulo, SP,Brazil. Electronic address: csnoto@gmail.com., Maes M; Graduation Program in Health Sciences, Universidade Estadual de Londrina, Londrina, PR, Brazil; Department of Psychiatry, Chulalongkorn University, Bangkok, Thailand., Bonifácio KL; Graduation Program in Health Sciences, Universidade Estadual de Londrina, Londrina, PR, Brazil., Brietzke E; LiNC-Interdisciplinary Laboratory of Clinical Neuroscience, Universidade Federal de Sao Paulo, SP, Brazil., Ota VK; LiNC-Interdisciplinary Laboratory of Clinical Neuroscience, Universidade Federal de Sao Paulo, SP, Brazil., Gadelha A; LiNC-Interdisciplinary Laboratory of Clinical Neuroscience, Universidade Federal de Sao Paulo, SP, Brazil., Cordeiro Q; LiNC-Interdisciplinary Laboratory of Clinical Neuroscience, Universidade Federal de Sao Paulo, SP, Brazil; First Episode Psychosis Program, Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP), São Paulo, SP,Brazil., Belangero SI; LiNC-Interdisciplinary Laboratory of Clinical Neuroscience, Universidade Federal de Sao Paulo, SP, Brazil., Bressan RA; LiNC-Interdisciplinary Laboratory of Clinical Neuroscience, Universidade Federal de Sao Paulo, SP, Brazil., Vargas HO; Graduation Program in Health Sciences, Universidade Estadual de Londrina, Londrina, PR, Brazil., Higachi L; Graduation Program in Health Sciences, Universidade Estadual de Londrina, Londrina, PR, Brazil., de Farias CC; Graduation Program in Health Sciences, Universidade Estadual de Londrina, Londrina, PR, Brazil., Moreira EG; Graduation Program in Health Sciences, Universidade Estadual de Londrina, Londrina, PR, Brazil., Barbosa DS; Graduation Program in Health Sciences, Universidade Estadual de Londrina, Londrina, PR, Brazil.
Jazyk: angličtina
Zdroj: Schizophrenia research [Schizophr Res] 2015 Aug; Vol. 166 (1-3), pp. 225-30. Date of Electronic Publication: 2015 Jun 27.
DOI: 10.1016/j.schres.2015.06.009
Abstrakt: Background: Activated immune-inflammatory pathways play an important role in the pathophysiology of schizophrenia. Paraoxonase 1 (PON1) activity is inversely associated with inflammatory responses in numerous clinical conditions. The aims of this study were to delineate serum arylesterase PON1 activity in drug-naïve first episode psychosis (FEP) patients and a healthy control group, and to assess whether there are inverse relationships between PON1 activity and cytokine levels.
Methods: A total of 51 drug-naïve FEP patients and 61 healthy controls were enrolled in this study. Levels of interleukin (IL)-4, IL-10, IL-6, tumor necrosis factor (TNF)-α and activity of PON1 were quantified.
Results: Compared to healthy controls, FEP patients showed lower serum PON1 activity and higher levels of IL-4, IL-10 and TNF-α. A significant inverse relationship between PON1 activity and IL-4, IL-6 and IL-10 levels was detected, but not for TNF-α. Subjects with very low PON1 activity (25th quartile) presented significantly higher levels of IL-6, IL-10 and IL-4 than those with higher PON1 activity (75th quartile).
Conclusion: The present study provides evidence that FEP is characterized by an inverse relationship between lowered activity of the anti-inflammatory/antioxidant enzyme PON1 and increased cytokine levels, including IL-6, IL-4 and IL-10. It is hypothesized that lowered PON1 activity may play a role in the immune-inflammatory response that accompanies FEP and that increased cytokine levels may further modulate PON1 activity.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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