Healing activity of Casearia sylvestris Sw. in second-degree scald burns in rodents.

Autor: de Campos EP; Laboratory for the Toxicological Research (Lapetox), Department of Pharmaceutical Sciences, University of Sorocaba (UNISO), Cidade Universitária, Rodovia Raposo Tavares km 92.5, 18023-000, Sorocaba, São Paulo, Brazil. ninoepd@hotmail.com., Trombini LN; Laboratory for the Toxicological Research (Lapetox), Department of Pharmaceutical Sciences, University of Sorocaba (UNISO), Cidade Universitária, Rodovia Raposo Tavares km 92.5, 18023-000, Sorocaba, São Paulo, Brazil. leticianavatrombini@yahoo.com.br., Rodrigues R; Laboratory for the Toxicological Research (Lapetox), Department of Pharmaceutical Sciences, University of Sorocaba (UNISO), Cidade Universitária, Rodovia Raposo Tavares km 92.5, 18023-000, Sorocaba, São Paulo, Brazil. rafaelaa_rodrigues@hotmail.com., Portella DL; Laboratory for the Toxicological Research (Lapetox), Department of Pharmaceutical Sciences, University of Sorocaba (UNISO), Cidade Universitária, Rodovia Raposo Tavares km 92.5, 18023-000, Sorocaba, São Paulo, Brazil. decioportella@yahoo.com.br., Werner AC; Laboratory for the Toxicological Research (Lapetox), Department of Pharmaceutical Sciences, University of Sorocaba (UNISO), Cidade Universitária, Rodovia Raposo Tavares km 92.5, 18023-000, Sorocaba, São Paulo, Brazil. adrianac.w@hotmail.com., Ferraz MC; Laboratory for the Toxicological Research (Lapetox), Department of Pharmaceutical Sciences, University of Sorocaba (UNISO), Cidade Universitária, Rodovia Raposo Tavares km 92.5, 18023-000, Sorocaba, São Paulo, Brazil. miriele.ferraz@gmail.com., de Oliveira RV; Laboratory for the Toxicological Research (Lapetox), Department of Pharmaceutical Sciences, University of Sorocaba (UNISO), Cidade Universitária, Rodovia Raposo Tavares km 92.5, 18023-000, Sorocaba, São Paulo, Brazil. robson.oliveira@prof.uniso.br., Cogo JC; Serpentarium of the Vale do Paraíba University (CEN-UNIVAP), Av Shishima Hifumi 2911, 12244-000, São José dos Campos, São Paulo, Brazil. jccogo@univap.br., Oshima-Franco Y; Laboratory for the Toxicological Research (Lapetox), Department of Pharmaceutical Sciences, University of Sorocaba (UNISO), Cidade Universitária, Rodovia Raposo Tavares km 92.5, 18023-000, Sorocaba, São Paulo, Brazil. yoko.franco@prof.uniso.br., Aranha N; Department of Technological and Environmental Process, University of Sorocaba (UNISO), Rodovia Raposo Tavares km 92.5, 18023-000, Sorocaba, São Paulo, Brazil. norberto.aranha@prof.uniso.br., Gerenutti M; Laboratory for the Toxicological Research (Lapetox), Department of Pharmaceutical Sciences, University of Sorocaba (UNISO), Cidade Universitária, Rodovia Raposo Tavares km 92.5, 18023-000, Sorocaba, São Paulo, Brazil. marli.gerenutti@prof.uniso.br.
Jazyk: angličtina
Zdroj: BMC research notes [BMC Res Notes] 2015 Jun 26; Vol. 8, pp. 269. Date of Electronic Publication: 2015 Jun 26.
DOI: 10.1186/s13104-015-1251-4
Abstrakt: Background: Every year thousands of people are victims of burns, mainly scald burns. Many of these victims have small size wounds and superficial partial thickness and do not seek specialized medical care. As in Brazil Casearia sylvestris Sw., popularly known as guaçatonga is widely used for its analgesic, antiseptic and anti-inflammatory activities, this study sought to evaluate the effects of its hydroalcoholic extract in healing process of burns injuries.
Methods: The obtained extract was validated applying a thin layer chromatography and sophisticated validation method using Bothrops jararacussu snake venom that is necrotic and inflammatory, and by which guaçatonga extract was able to neutralize the irreversible neuromuscular blockade induced by the venom. After induction of the scald injury, the animals were treated daily with saline solution spray; spray containing extract; biofilm; or biofilm impregnated with extract.
Results: Significant differences were observed between the four groups studied considering: extension of the healing area, neovascularization, fibroblast proliferation, and epithelialization.
Conclusion: The anti-inflammatory and bactericidal effects of C. sylvestris Sw. suggests a potential therapeutic benefit in the treatment of inflammatory conditions in second-degree scald burn injuries, as well as, counteracting against the in vitro paralysis induced by B. jararacussu venom.
Databáze: MEDLINE
Externí odkaz: