Deleterious effects of prepubertal corticosterone treatment on rat prostate.

Autor:	Pinto FC; Department of Surgery, Center for Health Sciences, Federal University of Pernambuco, Recife, PE, Brazil., Silva D; Department of Applied Mathematics, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Silva PC; UERJ, Rio de Janeiro, RJ, Brazil., Pereira LM; Department of Physiology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Morone AR; Department of Physiology, UNIRIO, Rio de Janeiro, RJ, Brazil., Costa WS; UERJ, Rio de Janeiro, RJ, Brazil., Cortez CM; UERJ, Rio de Janeiro, RJ, Brazil., Sampaio FJ; UERJ, Rio de Janeiro, RJ, Brazil.
Jazyk:	angličtina
Zdroj:	Acta cirurgica brasileira [Acta Cir Bras] 2015 Jun; Vol. 30 (6), pp. 382-7.
DOI:	10.1590/S0102-865020150060000002
Abstrakt:	Purpose: To investigate the structural and functional changes induced by corticosterone (CORT) in the ventral prostrate (VP) of rats in order to study chronic stress effects in the prepubertal phase. Methods: Wistar rats received daily saline or CORT injections during the pubertal period from the 5th to 25th day of postnatal life. The animals were distributed into four groups: 1 - Control (n=5); 2 - Control 99mTc-P (n=5); 3 - Treated with CORT (n=14); 4 - Treated with CORT and 99mTc-P (n=10). All rats were sacrificed at two months of age. Technical tissue uptakes of 99mTc-P were used to evaluate the functional and stereological methods for morphological analysis. Results: Acini distribution in the group treated with CORT differed significantly (p<0.0001) from the control. The control group's epithelial average height (10.01±0.24 microns) was statistically significant (p<0.0001) from rats treated with CORT (19.27±0.73microns). The collagen distribution was lower in the treated group (2.79%) when compared to control (3.97%). The radioactivity percentage in the groups marked with 99mTc-P (%Ati/g) did not demonstrate a statistically significant difference (p=0.285897). Conclusion: Chronic administration of corticosterone in prepubertal rats causes changes in their acinar structure and their ventral prostate stroma, indicating possible deleterious effects of this hormone.
Databáze:	MEDLINE
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