Evaluation of the cytokine mannose-binding lectin as a mediator of periportal fibrosis progression in patients with schistosomiasis.
| Autor: | Silva PC; Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Vitória de Santo Antão, Pernambuco, Brazil., Gomes AV; Laboratório de Biologia Molecular, Hospital Universitário Oswaldo Cruz, Universidade de Pernambuco, Recife, Pernambuco, Brazil., Cahu GG; Setor de Virologia do Laboratório de Imunopatologia Keizo-Asami, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil., Coêlho MR; Setor de Virologia do Laboratório de Imunopatologia Keizo-Asami, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil., Muniz MT; Laboratório de Biologia Molecular, Hospital Universitário Oswaldo Cruz, Universidade de Pernambuco, Recife, Pernambuco, Brazil., Domingues AL; Departamento de Medicina Clínica, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2015 May-Jun; Vol. 48 (3), pp. 350-3. |
| DOI: | 10.1590/0037-8682-0309-2014 |
| Abstrakt: | Introduction: We hypothesized higher mannose-binding lectin level and classic factors (i.e., age, sex, alcohol consumption, exposure, and specific treatment) are associated with the severity of periportal fibrosis in schistosomiasis. Methods: This cross-sectional study involved 79 patients infected with Schistosoma mansoni with severe or mild/moderate periportal fibrosis. Serum concentrations of mannose-binding lectin were obtained by enzyme-linked immunosorbent assay (ELISA). Results: Higher serum level of mannose-binding lectin was significantly associated with advanced periportal fibrosis. Conclusions: Mannose-binding lectin may contribute to liver pathology in schistosomiasis and may represent a risk factor for advanced periportal fibrosis in the Brazilian population studied. |
| Databáze: | MEDLINE |
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