Random urine albumin:creatinine ratio in high-risk pregnancy - Is it clinically useful?

Autor: De Silva DA; Department of Pathology and Laboratory Medicine, Children and Women's Health Centre of British Columbia and the University of British Columbia, Vancouver, Canada; Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada. Electronic address: Dane.DeSilva@cw.bc.ca., Halstead AC; Department of Pathology and Laboratory Medicine, Children and Women's Health Centre of British Columbia and the University of British Columbia, Vancouver, Canada. Electronic address: chalstead@cw.bc.ca., Côté AM; Department of Medicine, Université de Sherbrooke, Sherbrooke, Canada. Electronic address: Anne-Marie.Cote@USherbrooke.ca., Sabr Y; Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada. Electronic address: YSabr@cw.bc.ca., von Dadelszen P; Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada; Child and Family Research Institute, University of British Columbia, Vancouver, Canada. Electronic address: pdadelszen@cw.bc.ca., Magee LA; Department of Medicine, University of British Columbia, Vancouver, Canada; Department of Specialized Women's Health, British Columbia Women's Hospital and Health Centre, Vancouver, Canada; Child and Family Research Institute, University of British Columbia, Vancouver, Canada. Electronic address: LMagee@cw.bc.ca.
Jazyk: angličtina
Zdroj: Pregnancy hypertension [Pregnancy Hypertens] 2013 Apr; Vol. 3 (2), pp. 112-4. Date of Electronic Publication: 2013 Feb 18.
DOI: 10.1016/j.preghy.2013.02.001
Abstrakt: We evaluated the frequency of measurable albuminuria (⩾6.00mg/L) for albumin:creatinine ratios (ACr) among 160 consecutive women attending high-risk clinics. Of last urine samples before delivery, 76 had measurable albuminuria and 41/76 (53.9%) had ACr ⩾2mg/mmol of which 7.3% had normal pregnancy outcome. 84 samples had albuminuria <6.00mg/L and 43/84 (51.2%) had ACr ⩾2mg/mmol of which 25.6% had normal pregnancy outcome (p=0.025). Excluding 48/160 (30.0%) dilute samples (urinary creatinine <3mM), no samples with unmeasurable albuminuria had ACr ⩾2mg/mmol. In pregnancy, urine is often dilute and without measurable albuminuria, leading to a clinically relevant proportion of false positive results by ACr.
(Copyright © 2013 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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