Trophoblast calcyclin is elevated in placental tissue from patients with early pre-eclampsia.
Autor: | Schol PB; Dept. of Neurology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands; Dept. of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands; Dept. of Pathology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: p.b.b.schol@hotmail.com., Güzel C; Dept. of Neurology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: c.guzel@erasmusmc.nl., Steegers EA; Dept. of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: e.a.p.steegers@erasmusmc.nl., de Krijger RR; Dept. of Pathology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: r.dekrijger@erasmusmc.nl., Luider TM; Dept. of Neurology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Electronic address: t.luider@erasmusmc.nl. |
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Jazyk: | angličtina |
Zdroj: | Pregnancy hypertension [Pregnancy Hypertens] 2014 Jan; Vol. 4 (1), pp. 7-10. Date of Electronic Publication: 2013 Nov 19. |
DOI: | 10.1016/j.preghy.2013.11.003 |
Abstrakt: | The aetiology of pre-eclampsia is thought to originate from aberrant spiral artery remodelling and invasion evoking cellular oxidative stress. Previously, we discovered differentially expressed proteins in trophoblast cells of pre-eclamptic pregnancies. One of these proteins is calcyclin (S100A6); a Ca(2+)-binding protein associated with cellular stress response. By immunohistochemistry on formalin-fixed paraffin-embedded placental tissue, calcyclin expression was compared between women with early pre-eclampsia (n=72) and non-hypertensive control patients (n=66) (χ(2), p=0.006) blindly by two observers. Significantly more intense staining was seen in trophoblast cells of pre-eclamptic pregnancies compared to control placentas suggesting that trophoblast calcyclin is elevated in early pregnancy. (Copyright © 2013 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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