Adherence to the lymphadenectomy recommendations of the 2009 clinical guidelines in the 2010 National Prostate Cancer Registry.

Autor:	Herranz Amo F; Hospital Universitario Gregorio Marañón, Madrid, España. Electronic address: felipeherranz@telefonica.net., Hernández Fernández C; Hospital Universitario Gregorio Marañón, Madrid, España., Cózar Olmo JM; Hospital Virgen de las Nieves, Granada, España., Miñana López B; Hospital Morales Meseguer, Murcia, España., Gómez-Veiga F; Complejo Hospitalario Universitario de A Coruña, La Coruña, España., Rodríguez-Antolín A; Hospital Universitario 12 de Octubre, Madrid, España., Pedrosa E; Astellas Pharma, S.A., Madrid, España.
Jazyk:	English; Spanish; Castilian
Zdroj:	Actas urologicas espanolas [Actas Urol Esp] 2015 Nov; Vol. 39 (9), pp. 546-52. Date of Electronic Publication: 2015 Jun 19.
DOI:	10.1016/j.acuro.2015.05.004
Abstrakt:	Objective: To assess the adherence to the recommendations of the 2009 clinical guidelines in the implementation of lymphadenectomy during radical prostatectomy and analysis of the variables that influence this decision in the 2010 National Prostate Cancer Registry. Material and Method: Analysis of 1,272 patients who underwent prostatectomy in 25 national hospitals. Patient classification according to the pathological node-positive (pN+) risk criteria included in the clinical guidelines of the European Association of Urology (EAU) and National Comprehensive Cancer Network (NCCN). Calculation of the raw agreement and index of agreement kappa. Logistic regression to assess the predictors in the decision to perform lymphadenectomy. Results: Lymphadenectomy was performed on 225 (17.7%) patients, with a variability among centers of 0-62.2% (p<.001). There was lymphocytic invasion (pN+) in 17 (7.5%) patients. The raw agreement with the EAU-09 clinical guidelines was .672 (.48-.96 in the various centers), and the kappa index was .289. The raw agreement with the NCCN-09 clinical guidelines was.814 (.51-1 in the various centers), and the kappa index was .228. In the multivariate analysis, the independent predictors for performing lymphadenectomy were the Gleason score, the clinical stage, the prostate-specific antigen, the hospital center and the surgical approach route to prostatectomy (all P<.001). Conclusions: In our study, adherence to the recommendations of the clinical guidelines on the implementation of lymphadenectomy was moderate. When deciding on lymphadenectomy, the determinants (in addition to the classic clinical variables) were the approach route and the hospital where the prostatectomy was performed. (Copyright © 2015 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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