Oxidative Decarboxylation of Short-Chain Fatty Acids to 1-Alkenes.

Autor: Dennig A; Department of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz (Austria)., Kuhn M; Department of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz (Austria)., Tassoti S; Department of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz (Austria)., Thiessenhusen A; Creavis, Evonik Industries, Bau 1420, Paul Baumann Strasse 1, 45772 Marl (Germany)., Gilch S; Creavis, Evonik Industries, Bau 1420, Paul Baumann Strasse 1, 45772 Marl (Germany)., Bülter T; Creavis, Evonik Industries, Bau 1420, Paul Baumann Strasse 1, 45772 Marl (Germany)., Haas T; Creavis, Evonik Industries, Bau 1420, Paul Baumann Strasse 1, 45772 Marl (Germany)., Hall M; Department of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz (Austria)., Faber K; Department of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz (Austria). Kurt.Faber@Uni-Graz.at.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2015 Jul 20; Vol. 54 (30), pp. 8819-22. Date of Electronic Publication: 2015 Jun 11.
DOI: 10.1002/anie.201502925
Abstrakt: The enzymatic oxidative decarboxylation of linear short-chain fatty acids (C4:0-C9:0) employing the P450 monooxygenase OleT, O2 as the oxidant, and NAD(P)H as the electron donor gave the corresponding terminal C3 to C8  alkenes with product titers of up to 0.93 g L(-1) and TTNs of >2000. Key to this process was the construction of an efficient electron-transfer chain employing putidaredoxin CamAB in combination with NAD(P)H recycling at the expense of glucose, formate, or phosphite. This system allows for the biocatalytic production of industrially important 1-alkenes, such as propene and 1-octene, from renewable resources for the first time.
(© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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