Hypoxia in astrocytic tumors and implications for therapy.

Autor:	Cavazos DA; Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA., Brenner AJ; Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. Electronic address: brennera@uthscsa.edu.
Jazyk:	angličtina
Zdroj:	Neurobiology of disease [Neurobiol Dis] 2016 Jan; Vol. 85, pp. 227-233. Date of Electronic Publication: 2015 Jun 19.
DOI:	10.1016/j.nbd.2015.06.007
Abstrakt:	Glioblastoma (GBM, Grade IV astrocytoma) is the most common and most aggressive of the primary malignant brain tumors in adults. Hypoxia is a distinct feature in GBM and plays a significant role in tumor progression, resistance to treatment and poor outcomes. This review considers the effects of hypoxia on astrocytic tumors and the mechanisms that contribute to tumor progression and therapeutic resistance, with a focus on the vascular changes, chemotaxic signaling pathways and metabolic alterations involved. (Copyright © 2015 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Full Text from ScienceDirect