Application of small-angle X-ray scattering to the characterization and quantification of the drug transport nanosystem based on the soybean phosphatidylcholine.

Autor: Kiselev MA; Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia. Electronic address: kiselev@nf.jinr.ru., Zemlyanaya EV; Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia., Ipatova OM; V.N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia., Gruzinov AY; National Research Center «Kurchatov Institute», Moscow, Russia., Ermakova EV; Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia., Zabelin AV; National Research Center «Kurchatov Institute», Moscow, Russia., Zhabitskaya EI; Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia; International University 'Dubna', Dubna, Moscow Region 141980 Russia., Druzhilovskaya OS; V.N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia., Aksenov VL; Joint Institute for Nuclear Research, 141980 Dubna, Moscow Region, Russia; Petersburg Nuclear Physics Institute, NRC «Kurchatov Institute», Gatchina, Russia.
Jazyk: angličtina
Zdroj: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2015 Oct 10; Vol. 114, pp. 288-91. Date of Electronic Publication: 2015 Jun 01.
DOI: 10.1016/j.jpba.2015.05.034
Abstrakt: Phospholipid transport nanosystem (PTNS) for drug delivery is based on soybean phosphatidylcholine. The morphology of PTNS is investigated by means of small-angle X-ray scattering. The obtained results allow one to answer the key question from the viewpoint of organization of drug incorporation whether the PTNS nanoparticles have a structure of micelles or vesicles. It is demonstrated that PTNS is a vesicular system with an average vesicle radius of 160 ± 2Å.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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