Albiglutide: A once-weekly glucagon-like peptide-1 receptor agonist for type 2 diabetes mellitus.
| Autor: | Davis PN; Portia N. Davis, Pharm.D., is Assistant Professor of Pharmacy Practice, Texas Southern University (TSU) College of Pharmacy and Health Sciences, and Clinical Pharmacy Specialist, Ambulatory Care, San José Clinic, Houston. Uche Anadu Ndefo, Pharm.D., BCPS, is Associate Professor of Pharmacy Practice; Ashley Oliver is a Pharm.D. student; and Enryka Payton is a Pharm.D. student, TSU College of Pharmacy and Health Sciences. davisp@tsu.edu., Ndefo UA; Portia N. Davis, Pharm.D., is Assistant Professor of Pharmacy Practice, Texas Southern University (TSU) College of Pharmacy and Health Sciences, and Clinical Pharmacy Specialist, Ambulatory Care, San José Clinic, Houston. Uche Anadu Ndefo, Pharm.D., BCPS, is Associate Professor of Pharmacy Practice; Ashley Oliver is a Pharm.D. student; and Enryka Payton is a Pharm.D. student, TSU College of Pharmacy and Health Sciences., Oliver A; Portia N. Davis, Pharm.D., is Assistant Professor of Pharmacy Practice, Texas Southern University (TSU) College of Pharmacy and Health Sciences, and Clinical Pharmacy Specialist, Ambulatory Care, San José Clinic, Houston. Uche Anadu Ndefo, Pharm.D., BCPS, is Associate Professor of Pharmacy Practice; Ashley Oliver is a Pharm.D. student; and Enryka Payton is a Pharm.D. student, TSU College of Pharmacy and Health Sciences., Payton E; Portia N. Davis, Pharm.D., is Assistant Professor of Pharmacy Practice, Texas Southern University (TSU) College of Pharmacy and Health Sciences, and Clinical Pharmacy Specialist, Ambulatory Care, San José Clinic, Houston. Uche Anadu Ndefo, Pharm.D., BCPS, is Associate Professor of Pharmacy Practice; Ashley Oliver is a Pharm.D. student; and Enryka Payton is a Pharm.D. student, TSU College of Pharmacy and Health Sciences. |
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| Jazyk: | angličtina |
| Zdroj: | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists [Am J Health Syst Pharm] 2015 Jul 01; Vol. 72 (13), pp. 1097-103. |
| DOI: | 10.2146/ajhp140260 |
| Abstrakt: | Purpose: The pharmacology, pharmacokinetics, efficacy, safety, dosage and administration, and place in therapy of the glucagon-like peptide-1 (GLP-1) receptor agonist albiglutide are reviewed. Summary: Albiglutide (Tanzeum, GlaxoSmithKline) is an injectable GLP-1 agonist approved in 2014 for use as an adjunct to diet modification and exercise to improve glycemic control in adults with type 2 diabetes. Albiglutide augments glucose-dependent insulin secretion and slows gastric emptying; it has an elimination half-life of approximately five days, allowing for once-weekly administration. Clinical trials demonstrated mean absolute reductions in glycosylated hemoglobin (HbA1c) values of 0.78-1.55% after 16 weeks of adjunctive therapy with albiglutide. Specific recommendations on albiglutide use have been issued by the American Association of Clinical Endocrinologists (AACE) and the American Diabetes Association (ADA). Studies show that the potential for hypoglycemic episodes with albiglutide use is low. In clinical trials, the most frequently reported adverse events were nausea and diarrhea. The use of albiglutide is contraindicated in patients with a history of pancreatitis and patients with a personal or family history of thyroid cancer. Conclusion: Albiglutide has been shown to be effective for the management of type 2 diabetes in adults and is recommended (by ADA) as second-line therapy when used in combination with metformin and (by AACE) as first-line monotherapy in patients with an HbA1c concentration of ≤7.5% at treatment initiation. In clinical trials, albiglutide was generally well tolerated by patients, with adverse effects comparable to those seen with other GLP-1 agonists. (Copyright © 2015 by the American Society of Health-System Pharmacists, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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