Effect of gestational subclinical hypothyroidism on early neurodevelopment of offspring.

Autor:	Chen LM; Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.; Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China., Chen QS; Department of Endocrinology, Wenzhou People's Hospital, Wenzhou, China., Jin GX; Department of Pediatrics, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China., Si GX; Department of Endocrinology, Jining First People's Hospital, Jining, China., Zhang Q; ICU, Taizhou First People's Hospital, Taizhou, China., Ye EL; Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.; Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China., Yang H; Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.; Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China., Cai LQ; Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.; Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China., Peng MM; Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.; Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China., Lin ZZ; Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.; Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China., Yu LC; Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.; Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China., Zhang C; Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China., Lu XM; Department of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Rui'an, China.; Rui'an Center of the Chinese-American Research Institute for Diabetic Complications, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical University, Wenzhou, China.
Jazyk:	angličtina
Zdroj:	Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2015 Sep; Vol. 35 (9), pp. 678-82. Date of Electronic Publication: 2015 Jun 18.
DOI:	10.1038/jp.2015.66
Abstrakt:	Objective: To evaluate the effects of gestational subclinical hypothyroidism (SCH) on early neurodevelopment of offspring. Study Design: A prospective study included 106 infants born to mothers with gestational SCH and 106 infants born to mothers who were euthyroid during pregnancy. The neurodevelopment of 12 to 24-month-old infants was assessed and compared using the Gesell developmental test (revised version). Results: Infants born to mothers with gestational SCH and those born to euthyroid mothers had similar scores on the Gesell development test. No correlations were observed between maternal TSH concentration and Gesell developmental test scores of offspring. Infants born to mothers who had gestational SCH during the first trimester specifically and those born to euthyroid mothers had similar scores on the Gesell development test. No significant correlations were detected between maternal TSH concentration during the first trimester and offspring neurodevelopment. Conclusions: No detectable neurodevelopment deficit was observed in offspring up to 24 months old from mothers who had gestational SCH.
Databáze:	MEDLINE
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