| Autor: |
Popov BV; Institute of Cytology, Russian Academy of Science, St. Petersburg, Russia, borisvp478@gmail.com., Shilo PS, Zhidkova OV, Zaichik AM, Petrov NS |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2015 Jun; Vol. 159 (2), pp. 289-92. Date of Electronic Publication: 2015 Jun 19. |
| DOI: |
10.1007/s10517-015-2944-3 |
| Abstrakt: |
Using stable constitutive expression of retinoblastoma gene product (pRb) in polypotent mesenchymal 10T1/2 cells we obtained stable cell lines hyperexpressing functionally active or inactive mutant pRb. The cells producing active exogenous pRb demonstrated high sensitivity to adipocyte differentiation inductors, whereas production of inactive form of the exogenous protein suppressed adipocyte differentiation. The obtained lines can serve as the experimental model for studying the role of pRb in determination of adipocyte differentiation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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