| Autor: |
Phaelante A; Cardiovascular Research Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos 2350, Porto Alegre, RS, 90035-003, Brazil, a.phpinto@gmail.com., Rohde LE, Lopes A, Olsen V, Tobar SA, Cohen C, Martinelli N, Biolo A, Dal-Pizzol F, Clausell N, Andrades M |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2015 Jul; Vol. 8 (5), pp. 328-37. Date of Electronic Publication: 2015 Jun 18. |
| DOI: |
10.1007/s12265-015-9633-5 |
| Abstrakt: |
The antioxidant N-acetycysteine can turn into a prooxidant molecule in presence of iron ions. Thus, our goal was to test if the association of N-acetylcysteine (NAC) and an iron chelator (deferoxamine--DFX) in a rodent model of acute myocardial infarction (AMI) improves cardiac function. Male Wistar rats were subjected to a SHAM surgery or AMI. The animals were randomized: vehicle, NAC (25 mg/kg for 28 days), DFX (40 mg/kg for 7 days), or NAC plus DFX (NAC plus DFX, respectively). Animals were killed 28 days after the AMI. Animals treated with NAC/DFX showed an increase in left ventricular ejection fraction at 28 days when compared with vehicle group (45.2 ± 10.9 % vs. 34.7 ± 8.7 %, p = 0.03). Antioxidant effect of NAC/DFX treatment decreased 4-hydroxynonenal when compared to AMI group (p = 0.06). In conclusion, we showed beneficial effect of NAC/DFX association in improving left ventricle function in an experimental AMI. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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