| Autor: |
Azizova TV; Southern Urals Biophysics Institute, 19 Ozyorskoe shosse, Ozyorsk, 456780, Chelyabinsk Region, Russia., Grigorieva ES, Hunter N, Pikulina MV, Moseeva MB |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of radiological protection : official journal of the Society for Radiological Protection [J Radiol Prot] 2015 Sep; Vol. 35 (3), pp. 517-38. Date of Electronic Publication: 2015 Jun 17. |
| DOI: |
10.1088/0952-4746/35/3/517 |
| Abstrakt: |
Mortality from circulatory diseases (CD) (ICD-9 codes 390-459) was studied in an extended Mayak worker cohort, which included 22,377 workers first employed at the Mayak Production Association in 1948-1982 and followed up to the end of 2008. The enlarged cohort and extended follow-up as compared to the previous analyses provided an increased number of deaths from CD and improved statistical power of this mortality study. The analyses were based on dose estimates provided by a new Mayak Worker Dosimetry System 2008 (MWDS-2008). For the first time in the study of non-cancer effects in this cohort quantitative smoking data (smoking index) were taken into account. A significant increasing trend for CD mortality with increasing dose from external gamma-rays was found after having adjusted for non-radiation factors; the excess relative risk per unit dose (ERR/Gy) was 0.05 (95% confidence interval (CI): >0, 0.11). Inclusion of an additional adjustment for dose from internal alpha-radiation to the liver resulted in a two-fold increase of ERR/Gy = 0.10 (95% CI: 0.02, 0.21). A significant increasing trend in CD mortality with increasing dose from internal alpha-radiation to the liver was observed (ERR/Gy = 0.27, 95% CI: 0.12, 0.48). However the ERR/Gy decreased and lost its significance after adjusting for dose from external gamma-rays. Results of the current study are in good agreement with risk estimates obtained for the Japanese LSS cohort as well as other studies of cohorts of nuclear workers. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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