Eosinophil count at intensive care unit admission was not predictor of hospital mortality: results of a case control study.

Autor: Escobar-Valdivia EJ; Department of Internal Medicine, 'Dr. José E. González' University Hospital, Nuevo León Autonomous University, Av. Francisco I. Madero1500, Suburb: Mitras Centro, Monterrey, NL 64460 Mexico., González-Aguirre JE; Department of Pulmonary and Critical Care Medicine, 'Dr. José E. González' University Hospital, Nuevo León Autonomous University, Av. Francisco I. Madero1500, Suburb: Mitras Centro, Monterrey, NL 64460 Mexico., Carrillo-Cisneros ER; Department of Internal Medicine, 'Dr. José E. González' University Hospital, Nuevo León Autonomous University, Av. Francisco I. Madero1500, Suburb: Mitras Centro, Monterrey, NL 64460 Mexico., Guerra-Leza KC; Department of Internal Medicine, 'Dr. José E. González' University Hospital, Nuevo León Autonomous University, Av. Francisco I. Madero1500, Suburb: Mitras Centro, Monterrey, NL 64460 Mexico., Mercado-Longoría R; Department of Pulmonary and Critical Care Medicine, 'Dr. José E. González' University Hospital, Nuevo León Autonomous University, Av. Francisco I. Madero1500, Suburb: Mitras Centro, Monterrey, NL 64460 Mexico.
Jazyk: angličtina
Zdroj: Journal of intensive care [J Intensive Care] 2015 Jun 06; Vol. 3 (1), pp. 27. Date of Electronic Publication: 2015 Jun 06 (Print Publication: 2015).
DOI: 10.1186/s40560-015-0093-4
Abstrakt: Background: Predicting mortality in the intensive care unit (ICU) is one of the biggest challenges in critical care medicine. Several studies have linked the presence of eosinopenia with adverse outcomes in different populations.
Methods: We performed a case control study to determine whether the eosinophil count at ICU admission was a predictor of hospital mortality. We included data from patients 18 years or older admitted to the medical or surgical ICU in a university hospital in northern of Mexico. Medical records of 86 non-survivors (cases) and 99 discharged alive patients (controls) were randomly reviewed; clinical records of patients with an ICU stay of less than 24 h and those whose information was incomplete were excluded.
Results: Median of eosinophil count at ICU admission was 0.013 (interquartile range (IQR) 0.00 to 0.57) K/μL. There was no significant statistical difference in eosinophils at admission between survivors and non-survivors (0.014 [IQR 0.00 to 0.36] vs. 0.010 [IQR 0.00 to 0.57] K/μL, P = 0.35). In the multivariate analysis, APACHE II score at ICU admission and discharge were the only mortality predictors. Survivors had a significantly greater increase in eosinophil count during the first 7 days of ICU stay (0.104 [IQR -0.64 to 0.41] vs. 0.005 [IQR -1.79 to 0.43] K/μL, P = 0.004).
Conclusions: In our study, eosinophil count at ICU admission was not associated with increased hospital mortality. The larger increase in number of eosinophils observed during the first week of ICU stay in surviving patients deserves to be investigated further.
Databáze: MEDLINE
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