| Autor: |
Suarez GV; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA, University of Buenos Aires School of Medicine, C1121ABG Buenos Aires, Argentina., Vecchione MB; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA, University of Buenos Aires School of Medicine, C1121ABG Buenos Aires, Argentina ; Unidad de Microanálisis y Métodos Físicos Aplicados a Química Orgánica (UMYMFOR), Department of Organic Chemistry, University of Buenos Aires School of Sciences, C1428EGA Buenos Aires, Argentina., Angerami MT; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA, University of Buenos Aires School of Medicine, C1121ABG Buenos Aires, Argentina., Sued O; J.A. Fernández Hospital, Infectious Diseases Unit, C1425AGP Buenos Aires, Argentina ; Huesped Foundation, C1202ABB Buenos Aires, Argentina., Bruttomesso AC; Unidad de Microanálisis y Métodos Físicos Aplicados a Química Orgánica (UMYMFOR), Department of Organic Chemistry, University of Buenos Aires School of Sciences, C1428EGA Buenos Aires, Argentina., Bottasso OA; Instituto de Inmunología Clínica y Experimental de Rosario (IDICER), CONICET-UNR, Rosario, S2002LRL Santa Fe, Argentina., Quiroga MF; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA, University of Buenos Aires School of Medicine, C1121ABG Buenos Aires, Argentina. |
| Abstrakt: |
Worldwide, around 14 million individuals are coinfected with both tuberculosis (TB) and human immunodeficiency virus (HIV). In coinfected individuals, both pathogens weaken immunological system synergistically through mechanisms that are not fully understood. During both HIV and TB infections, there is a chronic state of inflammation associated to dramatic changes in immune cytokine and endocrine hormone levels. Despite this, the relevance of immunoendocrine interaction on both the orchestration of an effective immune response against both pathogens and the control of the chronic inflammation induced during HIV, TB, or both infections is still controversial. The present study reviews immunoendocrine interactions occurring during HIV and TB infections. We also expose our own findings on immunoendocrine cross talk in HIV-TB coinfection. Finally, we evaluate the use of adrenal hormones and their derivatives in immune-therapy and discuss the use of some of these compounds like the adjuvant for the prevention and treatment of TB in HIV patients. |
