A program to analyse optical coherence tomography images of the ciliary muscle.

Autor: Laughton DS; Ophthalmic Research Group, Life & Health Sciences, Aston University, Birmingham B4 7ET, UK., Coldrick BJ; Ophthalmic Research Group, Life & Health Sciences, Aston University, Birmingham B4 7ET, UK; Biomedical Engineering, Life & Health Sciences, Aston University, Birmingham, UK., Sheppard AL; Ophthalmic Research Group, Life & Health Sciences, Aston University, Birmingham B4 7ET, UK., Davies LN; Ophthalmic Research Group, Life & Health Sciences, Aston University, Birmingham B4 7ET, UK.
Jazyk: angličtina
Zdroj: Contact lens & anterior eye : the journal of the British Contact Lens Association [Cont Lens Anterior Eye] 2015 Dec; Vol. 38 (6), pp. 402-8. Date of Electronic Publication: 2015 Jun 10.
DOI: 10.1016/j.clae.2015.05.007
Abstrakt: Purpose: To describe and validate bespoke software designed to extract morphometric data from ciliary muscle Visante Anterior Segment Optical Coherence Tomography (AS-OCT) images.
Method: Initially, to ensure the software was capable of appropriately applying tiered refractive index corrections and accurately measuring orthogonal and oblique parameters, 5 sets of custom-made rigid gas-permeable lenses aligned to simulate the sclera and ciliary muscle were imaged by the Visante AS-OCT and were analysed by the software. Human temporal ciliary muscle data from 50 participants extracted via the internal Visante AS-OCT caliper method and the software were compared. The repeatability of the software was also investigated by imaging the temporal ciliary muscle of 10 participants on 2 occasions.
Results: The mean difference between the software and the absolute thickness measurements of the rigid gas-permeable lenses were not statistically significantly different from 0 (t=-1.458, p=0.151). Good correspondence was observed between human ciliary muscle measurements obtained by the software and the internal Visante AS-OCT calipers (maximum thickness t=-0.864, p=0.392, total length t=0.860, p=0.394). The software extracted highly repeatable ciliary muscle measurements (variability ≤6% of mean value).
Conclusion: The bespoke software is capable of extracting accurate and repeatable ciliary muscle measurements and is suitable for analysing large data sets.
(Copyright © 2015 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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