| Autor: |
Johnson CM; Department of Biology, Georgia State University, 50 Decatur Street, Atlanta, GA, 30302, USA., Cui N, Zhong W, Oginsky MF, Jiang C |
| Jazyk: |
angličtina |
| Zdroj: |
The journal of physiological sciences : JPS [J Physiol Sci] 2015 Sep; Vol. 65 (5), pp. 451-9. Date of Electronic Publication: 2015 Jun 13. |
| DOI: |
10.1007/s12576-015-0384-5 |
| Abstrakt: |
Rett syndrome (RTT) is a female neurodevelopmental disease with breathing abnormalities. To understand whether breathing defects occur in the early lives of a group of female Mecp2(+/-) mice, a mouse model of RTT, and what percentage of mice shows RTT-like breathing abnormality, breathing activity was measured by plethysmography in conscious mice. Breathing frequency variation and central apnea in a group of Mecp2(+/-) females displayed a distribution pattern similar to Mecp2(-/Y) males, while the rest resembled the wild-type mice. Similar results were obtained using the k-mean clustering statistics analysis. With two independent methods, about 20% of female Mecp2(+/-) mice showed RTT-like breathing abnormalities that began as early as 3 weeks of age in the Mecp2(+/-) mice, and were suppressed with 3% CO2. The finding that only a small proportion of Mecp2(+/-) mice develops RTT-like breathing abnormalities suggests incomplete allele inactivation in the RTT-model Mecp2(+/-) mice. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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