Diabetic nephropathy in Africa: A systematic review.

Autor:	Noubiap JJ; Jean Jacques N Noubiap, Internal Medicine Unit, Edéa Regional Hospital, PO BOX 100 Edéa, Cameroon., Naidoo J; Jean Jacques N Noubiap, Internal Medicine Unit, Edéa Regional Hospital, PO BOX 100 Edéa, Cameroon., Kengne AP; Jean Jacques N Noubiap, Internal Medicine Unit, Edéa Regional Hospital, PO BOX 100 Edéa, Cameroon.
Jazyk:	angličtina
Zdroj:	World journal of diabetes [World J Diabetes] 2015 Jun 10; Vol. 6 (5), pp. 759-73.
DOI:	10.4239/wjd.v6.i5.759
Abstrakt:	Aim: To determine the prevalence and incidence of diabetic nephropathy in Africa. Methods: We performed a systematic narrative review of published literature following the MOOSE Guidelines for Meta-Analysis and Systematic Reviews of Observational Studies. We searched PubMed-MEDLINE for all articles published in English and French languages between January 1994 and July 2014 using a predefined strategy based on the combination of relevant terms and the names of each of the 54 African countries and African sub-regions to capture the largest number of studies, and hand-searched the reference lists of retrieved articles. Included studies reported on the prevalence, incidence or determinants of chronic kidney disease (CKD) in people with diabetes within African countries. Results: Overall, we included 32 studies from 16 countries; two being population-based studies and the remaining being clinic-based surveys. Most of the studies (90.6%) were conducted in urban settings. Methods for assessing and classifying CKD varied widely. Measurement of urine protein was the most common method of assessing kidney damage (62.5% of studies). The overall prevalence of CKD varied from 11% to 83.7%. Incident event rates were 94.9% for proteinuria at 10 years of follow-up, 34.7% for end-stage renal disease at 5 years of follow-up and 18.4% for mortality from nephropathy at 20 years of follow-up. Duration of diabetes, blood pressure, advancing age, obesity and glucose control were the common determinants of kidney disease. Conclusion: The burden of CKD is important among people with diabetes in Africa. High quality data from large population-based studies with validated measures of kidney function are still needed to better capture the magnitude and characteristics of diabetic nephropathy in Africa.
Databáze:	MEDLINE
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