Salivary Flow Rates of Nigerian Patients with Chronic Kidney Disease: A Case-control Study.

Autor:	Oyetola EO; Lecturer and Consultant, Department of Preventive and Community Dentistry, Obafemi Awolowo University, Osun State, Nigeria Phone: 08035375713, e-mail: phemyhoye12@yahoo.com., Owotade FJ; Department of Oral and Maxillofacial Surgery and Oral Pathology, Obafemi Awolowo University, Ile Ife, Osun State Nigeria., Agbelusi GA; Department of Preventive Dentistry, Lagos University Teaching Hospital, Osun State, Nigeria., Fatusi O; Department of Oral and Maxillofacial Surgery and Oral Pathology, Obafemi Awolowo University, Ile Ife, Osun State Nigeria., Sanusi A; Department of Internal Medicine, Obafemi Awolowo University, Ile Ife, Osun State, Nigeria., Adesina OM; Department of Oral and Maxillofacial Surgery and Oral Pathology, Obafemi Awolowo University, Ile Ife, Osun State Nigeria.
Jazyk:	angličtina
Zdroj:	The journal of contemporary dental practice [J Contemp Dent Pract] 2015 Apr 01; Vol. 16 (4), pp. 264-9. Date of Electronic Publication: 2015 Apr 01.
DOI:	10.5005/jp-journals-10024-1673
Abstrakt:	Aims and Objectives: The study determined the relationship between chronic kidney disease (CKD) and changes in salivary flow and the complications of reduced salivary flow among African subjects with CKD compared with the controls. Materials and Methods: One hundred and eighty patients, 90 C KD and 90 controls were recruited, interviewed and examined. Stimulated and unstimulated saliva collection was done with standardized spitting method. Urinalysis and blood creatinine levels were determined and glomerular filtration rate (GFR) of each patient was calculated from the blood creatinine using Cockcroft and Gault formula. Statistical analysis was done using STATA 11 software. Results: The mean stimulated and unstimulated whole salivary flow rate among CKD subjects were 4.07 ± 1.91 and 2.34 ± 0.99 ml/5 min respectively and is significantly lower than that of the controls which were 8.05 ± 3.95 ml/5 min and 3.82 ± 2.27 ml/5 min for stimulated and unstimulated flow rates. Oral signs of reduced salivary flow were found in 80% of CKD patients. The commonest oral finding was taste abnormalities others are burning sensation, halitosis and difficulty in mastication. Conclusion: Patients with CKD had reduced stimulated and unstimulated salivary flow rate. Reduced salivary flow was associated with oral lesions in majority (80%) of CKD patients, the commonest finding being taste abnormalities.
Databáze:	MEDLINE
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