| Autor: |
Zhou H; Department of Agricultural Science, Faculty of Agricultural and Life Sciences, Lincoln University, Lincoln 7647, New Zealand., Cheng L; Department of Agricultural Science, Faculty of Agricultural and Life Sciences, Lincoln University, Lincoln 7647, New Zealand., Azimu W; College of Animal Science, Tarim University, Alar, Xinjiang Province 843300, China., Hodge S; Department of Agricultural Science, Faculty of Agricultural and Life Sciences, Lincoln University, Lincoln 7647, New Zealand., Edwards GR; Department of Agricultural Science, Faculty of Agricultural and Life Sciences, Lincoln University, Lincoln 7647, New Zealand., Hickford JG; Department of Agricultural Science, Faculty of Agricultural and Life Sciences, Lincoln University, Lincoln 7647, New Zealand. |
| Abstrakt: |
Fatty acid binding proteins (FABPs) bind long-chain fatty acids and are involved in their intracellular transport. Of the known bovine FABP genes, FABP4 has been mapped to a region on chromosome 14 that contains quantitative trait loci for milk traits. This study investigated the association of FABP4 haplotypes with milk production traits in 719 Holstein-Friesian × Jersey cows. Polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis of a variable region of the gene revealed three haplotypes (A, B and C). Five single nucleotide polymorphisms (SNPs) were identified: two in exon 3 and three in intron 3. A was associated (P=0.032) with increased milk protein percentage (present: 4.00 ± 0.02%; absent: 3.95 ± 0.02%) and B was associated (P=0.009) with increased milk yield (present: 23.81 ± 0.23 kg/d; absent: 23.06 ± 0.21 kg/d), but tended to be associated with a decrease in protein percentage and an increase in protein yield. Cows with genotypes AA, AB and AC produced less milk, but with a higher protein percentage than BC cows. This suggest that FABP4 affects milk yield and milk protein content, both economically important traits, and that further study of this gene is warranted. |
