Alcohol Consumption and Periodontitis: Quantification of Periodontal Pathogens and Cytokines.

Autor: Lages EJ; Department of Dental Clinics, Oral Pathology, and Dental Surgery; Faculty of Dentistry; Federal University of Minas Gerais; Belo Horizonte, Brazil., Costa FO; Department of Dental Clinics, Oral Pathology, and Dental Surgery; Faculty of Dentistry; Federal University of Minas Gerais; Belo Horizonte, Brazil., Cortelli SC; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil., Cortelli JR; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil., Cota LO; Department of Dental Clinics, Oral Pathology, and Dental Surgery; Faculty of Dentistry; Federal University of Minas Gerais; Belo Horizonte, Brazil., Cyrino RM; Department of Dental Clinics, Oral Pathology, and Dental Surgery; Faculty of Dentistry; Federal University of Minas Gerais; Belo Horizonte, Brazil., Lages EM; Department of Dental Clinics, Oral Pathology, and Dental Surgery; Faculty of Dentistry; Federal University of Minas Gerais; Belo Horizonte, Brazil., Nobre-Franco GC; Department of Dentistry, Periodontics Research Division, University of Taubaté, Taubaté, São Paulo, Brazil., Brito JA; Department of Dental Clinics, Oral Pathology, and Dental Surgery; Faculty of Dentistry; Federal University of Minas Gerais; Belo Horizonte, Brazil., Gomez RS; Department of Dental Clinics, Oral Pathology, and Dental Surgery; Faculty of Dentistry; Federal University of Minas Gerais; Belo Horizonte, Brazil.
Jazyk: angličtina
Zdroj: Journal of periodontology [J Periodontol] 2015 Sep; Vol. 86 (9), pp. 1058-68. Date of Electronic Publication: 2015 Jun 11.
DOI: 10.1902/jop.2015.150087
Abstrakt: Background: There are few studies on periodontal status related to microbiologic and immunologic profiles among individuals not or occasionally using alcohol and those with alcohol dependence. The aim of this study is to determine the effect of alcohol consumption on the levels of subgingival periodontal pathogens and proinflammatory cytokines (interleukin [IL]-1β and tumor necrosis factor [TNF]-α) in the gingival fluid among individuals with and without periodontitis.
Methods: This observational analytic study includes 88 volunteers allocated in four groups (n = 22): individuals with alcohol dependence and periodontitis (ADP), individuals with alcohol dependence and without periodontitis (ADNP), individuals not or occasionally using alcohol with periodontitis (NAP), and individuals not or occasionally using alcohol without periodontitis (NANP). Levels of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Eikenella corrodens, and Fusobacterium nucleatum were determined by real-time polymerase chain reaction on the basis of the subgingival biofilm, and IL-1β and TNF-α were quantified by enzyme-linked immunosorbent assay in gingival fluid samples.
Results: Individuals with alcohol dependence showed worse periodontal status and higher levels of P. intermedia, E. corrodens, F. nucleatum, and IL-1β than non-users. No significant correlations between TNF-α and bacterial levels were observed. However, in the ADP group, higher levels of E. corrodens were correlated with higher levels of IL-1β.
Conclusion: A negative influence of alcohol consumption was observed on clinical and microbiologic periodontal parameters, as well as a slight influence on immunologic parameters, signaling the need for additional studies.
Databáze: MEDLINE
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