The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery.

Autor: Bern M; Centre for Immune Regulation (CIR) and Department of Biosciences, University of Oslo, N-0316 Oslo, Norway; CIR and Department of Immunology, Oslo University Hospital Rikshospitalet, Norway, PO Box 4950, N-0424 Oslo, Norway., Sand KM; Centre for Immune Regulation (CIR) and Department of Biosciences, University of Oslo, N-0316 Oslo, Norway; CIR and Department of Immunology, Oslo University Hospital Rikshospitalet, Norway, PO Box 4950, N-0424 Oslo, Norway., Nilsen J; CIR and Department of Immunology, Oslo University Hospital Rikshospitalet, Norway, PO Box 4950, N-0424 Oslo, Norway; Institute of Clinical Medicine, University of Oslo, N-0316 Oslo, Norway., Sandlie I; Centre for Immune Regulation (CIR) and Department of Biosciences, University of Oslo, N-0316 Oslo, Norway; CIR and Department of Immunology, Oslo University Hospital Rikshospitalet, Norway, PO Box 4950, N-0424 Oslo, Norway., Andersen JT; CIR and Department of Immunology, Oslo University Hospital Rikshospitalet, Norway, PO Box 4950, N-0424 Oslo, Norway.
Jazyk: angličtina
Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2015 Aug 10; Vol. 211, pp. 144-62. Date of Electronic Publication: 2015 Jun 06.
DOI: 10.1016/j.jconrel.2015.06.006
Abstrakt: Albumin is the most abundant protein in blood and acts as a molecular taxi for a plethora of small insoluble substances such as nutrients, hormones, metals and toxins. In addition, it binds a range of medical drugs. It has an unusually long serum half-life of almost 3weeks, and although the structure and function of albumin has been studied for decades, a biological explanation for the long half-life has been lacking. Now, recent research has unravelled that albumin-binding cellular receptors play key roles in the homeostatic regulation of albumin. Here, we review our current understanding of albumin homeostasis with a particular focus on the impact of the cellular receptors, namely the neonatal Fc receptor (FcRn) and the cubilin-megalin complex, and we discuss their importance on uses of albumin in drug delivery.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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