E-selectin and P-selectin expression in endothelium of leprosy skin lesions.

Autor: Souza Jd; Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil., Sousa JR; Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil., Hirai KE; Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil., Silva LM; Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil., Fuzii HT; Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil., Dias LB Jr; Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil., Carneiro FR; Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil., Aarão TL; Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil., Quaresma JA; Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil; Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil. Electronic address: juarez@pesquisador.cnpq.br.
Jazyk: angličtina
Zdroj: Acta tropica [Acta Trop] 2015 Sep; Vol. 149, pp. 227-31. Date of Electronic Publication: 2015 Jun 05.
DOI: 10.1016/j.actatropica.2015.06.002
Abstrakt: Leprosy is an infectious-contagious disease whose clinical evolution depends on the immune response pattern of the host. Adhesion molecules and leukocyte migration from blood to tissue are of the utmost importance for the recognition and elimination of infectious pathogens. Selectins are transmembrane glycoproteins that share a similar structural organization and can be divided into three types according to their site of expression. The biopsies were cut into 5μm thick sections and submitted to immunohistochemistry using antibodies against E-selectin and P-selectin. The number of E-selectin-positive cells was significantly higher in the tuberculoid form than in the lepromatous form. The immunostaining pattern of P-selectin differed from that of E-selectin. Analysis showed a larger number of endothelial cells expressing CD62P in the lepromatous form compared to the tuberculoid form. The presence of these adhesins in the endothelium contributing to or impairing the recruitment of immune cells to inflamed tissue and consequently influences the pattern of immune response and the clinical presentation of the disease.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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