Genomic signatures of cooperation and conflict in the social amoeba.

Autor:	Ostrowski EA; Department of Biology and Biochemistry, University of Houston, Houston, TX 77204, USA. Electronic address: eaostrowski@uh.edu., Shen Y; Departments of Systems Biology and Biomedical Informatics, Columbia University, New York, NY 10027, USA., Tian X; Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA., Sucgang R; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Jiang H; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Qu J; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Katoh-Kurasawa M; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Brock DA; Department of Biology, Washington University in St. Louis, St. Louis, MO 63130, USA., Dinh C; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Lara-Garduno F; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Lee SL; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Kovar CL; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Dinh HH; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Korchina V; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Jackson L; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Patil S; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Han Y; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Chaboub L; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Shaulsky G; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Muzny DM; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Worley KC; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Gibbs RA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Richards S; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Kuspa A; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Strassmann JE; Department of Biology, Washington University in St. Louis, St. Louis, MO 63130, USA., Queller DC; Department of Biology, Washington University in St. Louis, St. Louis, MO 63130, USA.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2015 Jun 15; Vol. 25 (12), pp. 1661-5. Date of Electronic Publication: 2015 Jun 04.
DOI:	10.1016/j.cub.2015.04.059
Abstrakt:	Cooperative systems are susceptible to invasion by selfish individuals that profit from receiving the social benefits but fail to contribute. These so-called "cheaters" can have a fitness advantage in the laboratory, but it is unclear whether cheating provides an important selective advantage in nature. We used a population genomic approach to examine the history of genes involved in cheating behaviors in the social amoeba Dictyostelium discoideum, testing whether these genes experience rapid evolutionary change as a result of conflict over spore-stalk fate. Candidate genes and surrounding regions showed elevated polymorphism, unusual patterns of linkage disequilibrium, and lower levels of population differentiation, but they did not show greater between-species divergence. The signatures were most consistent with frequency-dependent selection acting to maintain multiple alleles, suggesting that conflict may lead to stalemate rather than an escalating arms race. Our results reveal the evolutionary dynamics of cooperation and cheating and underscore how sequence-based approaches can be used to elucidate the history of conflicts that are difficult to observe directly. (Copyright © 2015 Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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