Accumulation of organotins in seafood leads to reproductive tract abnormalities in female rats.

Autor: Podratz PL; Department of Morphology, Federal University of Espírito Santo, Brazil., Merlo E; Department of Morphology, Federal University of Espírito Santo, Brazil., Sena GC; Department of Morphology, Federal University of Espírito Santo, Brazil., Morozesk M; Department of Biological Sciences, Federal University of Espírito Santo, Brazil., Bonomo MM; Department of Biological Sciences, Federal University of Espírito Santo, Brazil., Matsumoto ST; Department of Biological Sciences, Federal University of Espírito Santo, Brazil., da Costa MB; Department of Biological Sciences, Federal University of Espírito Santo, Brazil., Zamprogno GC; Department of Biological Sciences, Federal University of Espírito Santo, Brazil., Brandão PA; Department of Chemistry, Federal University of Espírito Santo, Brazil., Carneiro MT; Department of Chemistry, Federal University of Espírito Santo, Brazil., Miguel Ede C; Department of Biochemistry and Molecular Biology, Federal University of Ceara, Brazil., Miranda-Alves L; Experimental Endocrinology Research Group, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil., Silva IV; Department of Morphology, Federal University of Espírito Santo, Brazil., Graceli JB; Department of Morphology, Federal University of Espírito Santo, Brazil. Electronic address: jbgraceli@gmail.com.
Jazyk: angličtina
Zdroj: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2015 Nov; Vol. 57, pp. 29-42. Date of Electronic Publication: 2015 Jun 04.
DOI: 10.1016/j.reprotox.2015.05.003
Abstrakt: Organotins (OTs) are environmental contaminants used as biocides in antifouling paints that have been shown to be endocrine disrupters. However, studies evaluating the effects of OTs accumulated in seafood (LNI) on reproductive health are particularly sparse. This study demonstrates that LNI leads to impairment in the reproductive tract of female rats, as the estrous cycle development, as well as for ovary and uterus morphology. Rats were treated with LNI, and their reproductive morphophysiology was assessed. Morphophysiological abnormalities, such as irregular estrous cycles, abnormal ovarian follicular development and ovarian collagen deposition, were observed in LNI rats. An increase in luminal epithelia and ERα expression was observed in the LNI uteri. Together, these data provide in vivo evidence that LNI are toxic for reproductive morphophysiology, which may be associated with risks to reproductive function.
(Copyright © 2015 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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