[The synthesis of ψ-(2-aryl-1,3-dioxolan-2-yl) alkyl derivatives of purines and their activity towards HIV reverse transcriptase].

Autor: Komissarov VV, Valuev-Elliston VT, Ivanova ON, Kochetkov SN, Kritzyn AM
Jazyk: ruština
Zdroj: Bioorganicheskaia khimiia [Bioorg Khim] 2015 Jan-Feb; Vol. 41 (1), pp. 44-53.
DOI: 10.1134/s1068162015010069
Abstrakt: Novel non-competitive inhibitors of HIV RT were synthesized by alkylation of 6-substituted purines with different 2-(chloroalkyl)-2-aryl-1,3-dioxolanes and related compounds. The structure-activity relationship within the synthesized compounds was studied.
Databáze: MEDLINE