Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European 3T study on healthy elderly.

Autor:	Marizzoni M; LENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS San Giovanni Di Dio-FBF, Brescia, Italy., Antelmi L; Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland., Bosch B; Department of Psychiatry and Clinical Psychobiology, Universitat De Barcelona and IDIBAPS, Barcelona, Spain., Bartrés-Faz D; Department of Psychiatry and Clinical Psychobiology, Universitat De Barcelona and IDIBAPS, Barcelona, Spain., Müller BW; LVR-Clinic for Psychiatry and Psychotherapy, Institutes and Clinics of the University Duisburg-Essen, Essen, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University, Göttingen, Germany., Fiedler U; LVR-Clinic for Psychiatry and Psychotherapy, Institutes and Clinics of the University Duisburg-Essen, Essen, Germany., Roccatagliata L; Department of Neuroradiology, IRCSS San Martino University Hospital and IST, Genoa, Italy.; Department of Health Sciences, University of Genoa, Genoa, Italy., Picco A; Department of Neuroscience, Ophthalmology, Genetics and Mother-Child Health (DINOGMI), University of Genoa, Genoa, Italy., Nobili F; Department of Neuroscience, Ophthalmology, Genetics and Mother-Child Health (DINOGMI), University of Genoa, Genoa, Italy., Blin O; Pharmacology, Assistance Publique - Hôpitaux De Marseille, Aix-Marseille University - CNRS, UMR 7289, Marseille, France., Bombois S; Department of Neurology, INSERM U1171, Lille University, Lille, France., Lopes R; Department of Neuroradiology, INSERM U1171, Lille University, Lille, France., Sein J; CRMBM-CEMEREM, UMR 7339, Aix Marseille Université - CNRS, Marseille, France., Ranjeva JP; CRMBM-CEMEREM, UMR 7339, Aix Marseille Université - CNRS, Marseille, France., Didic M; Service de Neurologie et Neuropsychologie, APHM, CHU Timone, Marseille, France.; Aix-Marseille Université, Inserm, INS UMR_S 1106, 13005, Marseille, France., Gros-Dagnac H; Imagerie Cérébrale Et Handicaps Neurologiques, INSERM, Toulouse, F, 31024, France.; Université Toulouse 3 Paul Sabatier, UMR 825 Imagerie Cérébrale Et Handicaps Neurologiques, Toulouse, F, 31024, France., Payoux P; Imagerie Cérébrale Et Handicaps Neurologiques, INSERM, Toulouse, F, 31024, France.; Université Toulouse 3 Paul Sabatier, UMR 825 Imagerie Cérébrale Et Handicaps Neurologiques, Toulouse, F, 31024, France., Zoccatelli G; Service of Neuroradiology, University Hospital of Verona, Verona, Italy., Alessandrini F; Service of Neuroradiology, University Hospital of Verona, Verona, Italy., Beltramello A; Service of Neuroradiology, University Hospital of Verona, Verona, Italy., Bargalló N; Department of Neuroradiology and Magnetic Resonace Image Core Facility, Hospital Clínic De Barcelona, IDIBAPS, Barcelona, Spain., Ferretti A; Department of Neuroscience, Imaging and Clinical Sciences, University 'G. d'Annunzio' of Chieti, Italy.; Institute for Advanced Biomedical Technologies (ITAB), University 'G. d'Annunzio' of Chieti, Italy., Caulo M; Department of Neuroscience, Imaging and Clinical Sciences, University 'G. d'Annunzio' of Chieti, Italy.; Institute for Advanced Biomedical Technologies (ITAB), University 'G. d'Annunzio' of Chieti, Italy., Aiello M; IRCCS SDN, Naples, Italy., Cavaliere C; IRCCS SDN, Naples, Italy., Soricelli A; IRCCS SDN, Naples, Italy.; University of Naples Parthenope, Naples, Italy., Salvadori N; Section of Neurology, Centre for Memory Disturbances, University of Perugia, Perugia, Italy., Parnetti L; Section of Neurology, Centre for Memory Disturbances, University of Perugia, Perugia, Italy., Tarducci R; Medical Physics Unit, Perugia General Hospital, Perugia, Italy., Floridi P; Neuroradiology Unit, Perugia General Hospital, Perugia, Italy., Tsolaki M; 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece., Constantinidis M; Interbalkan Medical Center of Thessaloniki, Thessaloniki, Greece., Drevelegas A; Interbalkan Medical Center of Thessaloniki, Thessaloniki, Greece.; Department of Radiology, Aristotle University of Thessaloniki, Thessaloniki, Greece., Rossini PM; Deptartment of Geriatrics, Neuroscience and Orthopaedics, Catholic University, Policlinic Gemelli, Rome, Italy.; IRCSS S.Raffaele Pisana, Rome, Italy., Marra C; Center for Neuropsychological Research, Catholic University, Rome, Italy., Hoffmann KT; Department of Neuroradiology, University Hospital Leipzig, Leipzig, Germany., Hensch T; Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany., Schönknecht P; Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Leipzig, Germany., Kuijer JP; Deptartment of Physics and Medical Technology, VU University Medical Center, Amsterdam, the Netherlands., Visser PJ; Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg, University of Maastricht, Maastricht, the Netherlands., Barkhof F; Radiology and Image Analysis Centre (IAC), VU University Medical Center, Amsterdam, the Netherlands., Bordet R; Department of Pharmacology, INSERM U1171, Lille University, Lille, France., Frisoni GB; LENITEM Laboratory of Epidemiology, Neuroimaging, & Telemedicine - IRCCS San Giovanni Di Dio-FBF, Brescia, Italy.; Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland., Jovicich J; Center for Mind/Brain Sciences (CIMEC), University of Trento, Rovereto, Italy.
Jazyk:	angličtina
Zdroj:	Human brain mapping [Hum Brain Mapp] 2015 Sep; Vol. 36 (9), pp. 3516-27. Date of Electronic Publication: 2015 Jun 03.
DOI:	10.1002/hbm.22859
Abstrakt:	Recently, there has been an increased interest in the use of automatically segmented subfields of the human hippocampal formation derived from magnetic resonance imaging (MRI). However, little is known about the test-retest reproducibility of such measures, particularly in the context of multisite studies. Here, we report the reproducibility of automated Freesurfer hippocampal subfields segmentations in 65 healthy elderly enrolled in a consortium of 13 3T MRI sites (five subjects per site). Participants were scanned in two sessions (test and retest) at least one week apart. Each session included two anatomical 3D T1 MRI acquisitions harmonized in the consortium. We evaluated the test-retest reproducibility of subfields segmentation (i) to assess the effects of averaging two within-session T1 images and (ii) to compare subfields with whole hippocampus volume and spatial reliability. We found that within-session averaging of two T1 images significantly improved the reproducibility of all hippocampal subfields but not that of the whole hippocampus. Volumetric and spatial reproducibility across MRI sites were very good for the whole hippocampus, CA2-3, CA4-dentate gyrus (DG), subiculum (reproducibility error∼2% and DICE > 0.90), good for CA1 and presubiculum (reproducibility error ∼ 5% and DICE ∼ 0.90), and poorer for fimbria and hippocampal fissure (reproducibility error ∼ 15% and DICE < 0.80). Spearman's correlations confirmed that test-retest reproducibility improved with volume size. Despite considerable differences of MRI scanner configurations, we found consistent hippocampal subfields volumes estimation. CA2-3, CA4-DG, and sub-CA1 (subiculum, presubiculum, and CA1 pooled together) gave test-retest reproducibility similar to the whole hippocampus. Our findings suggest that the larger hippocampal subfields volume may be reliable longitudinal markers in multisite studies. (© 2015 Wiley Periodicals, Inc.)
Databáze:	MEDLINE
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