A gorilla reservoir for human T-lymphotropic virus type 4.

Autor: LeBreton M; Mosaic, (Environment, Health, Data, Technology) , Yaoundé, Cameroon ; Global Viral Cameroon , BP 7039 Yaounde, Cameroon ; Metabiota , San Francisco, CA 94104, USA., Switzer WM; Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention , Atlanta, GA 30333, USA., Djoko CF; Global Viral Cameroon , BP 7039 Yaounde, Cameroon., Gillis A; Global Viral Cameroon , BP 7039 Yaounde, Cameroon ; Metabiota , San Francisco, CA 94104, USA., Jia H; Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention , Atlanta, GA 30333, USA., Sturgeon MM; Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention , Atlanta, GA 30333, USA., Shankar A; Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention , Atlanta, GA 30333, USA., Zheng H; Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention , Atlanta, GA 30333, USA., Nkeunen G; Global Viral Cameroon , BP 7039 Yaounde, Cameroon., Tamoufe U; Global Viral Cameroon , BP 7039 Yaounde, Cameroon ; Metabiota , San Francisco, CA 94104, USA., Nana A; Global Viral Cameroon , BP 7039 Yaounde, Cameroon., Le Doux Diffo J; Global Viral Cameroon , BP 7039 Yaounde, Cameroon., Tafon B; Ape Action Africa, Cameroon , BP 20072 Yaounde, Cameroon., Kiyang J; Limbe Wildlife Centre , Limbe, Cameroon., Schneider BS; Metabiota , San Francisco, CA 94104, USA., Burke DS; Graduate School of Public Health, University of Pittsburgh , Pittsburgh, PA 15213, USA., Wolfe ND; Metabiota , San Francisco, CA 94104, USA ; Program in Human Biology, Stanford University , Stanford, CA 94305, USA ; Global Viral , San Francisco, CA 94104, USA.
Jazyk: angličtina
Zdroj: Emerging microbes & infections [Emerg Microbes Infect] 2014 Jan; Vol. 3 (1), pp. e7. Date of Electronic Publication: 2014 Jan 22.
DOI: 10.1038/emi.2014.7
Abstrakt: Of the seven known species of human retroviruses only one, human T-cell lymphotropic virus type 4 (HTLV-4), lacks a known animal reservoir. We report the largest screening for simian T-cell lymphotropic virus (STLV-4) to date in a wide range of captive and wild non-human primate (NHP) species from Cameroon. Among the 681 wild and 426 captive NHPs examined, we detected STLV-4 infection only among gorillas by using HTLV-4-specific quantitative polymerase chain reaction. The large number of samples analyzed, the diversity of NHP species examined, the geographic distribution of infected animals relative to the known HTLV-4 case, as well as detailed phylogenetic analyses on partial and full genomes, indicate that STLV-4 is endemic to gorillas, and that rather than being an ancient virus among humans, HTLV-4 emerged from a gorilla reservoir, likely through the hunting and butchering of wild gorillas. Our findings shed further light on the importance of gorillas as keystone reservoirs for the evolution and emergence of human infectious diseases and provide a clear course for preventing HTLV-4 emergence through management of human contact with wild gorillas, the development of improved assays for HTLV-4/STLV-4 detection and the ongoing monitoring of STLV-4 among gorillas and for HTLV-4 zoonosis among individuals exposed to gorilla populations.
Databáze: MEDLINE
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