Pre- and Posttransplant IgA Anti-Fab Antibodies to Predict Long-term Kidney Graft Survival.

Autor: Amirzargar MA; Department of Urology, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran., Amirzargar A; Molecular Immunology Research Center, Medical School, Tehran University of Medical Sciences, Tehran, Iran., Basiri A; Urology Research Center, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Hajilooi M; Immunology Department, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran., Roshanaei G; Research Center for Health Science, Department of Biostatistics and Epidemiology, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran., Rajabi G; Department of Urology, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran., Solgi G; Immunology Department, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran; Psoriasis Research Center, Department of Dermatology, Farshchian Hospital, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: gh.solgi@umsha.ac.ir.
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2015 May; Vol. 47 (4), pp. 1110-3.
DOI: 10.1016/j.transproceed.2014.11.065
Abstrakt: Objectives: Immunologic factors are reliable markers for allograft monitoring, because of their seminal role in rejection process. One of these factors is the immunoglobulin (Ig)A anti-Fab of the IgG antibody. This study aimed to evaluate the predictive value of pre- and posttransplant levels of this marker for kidney allograft function and survival.
Methods: Sera samples of 59 living unrelated donor kidney recipients were collected before and after transplantation (days 7, 14, and 30) and investigated for IgA anti-Fab of IgG antibody levels using enzyme-linked immunosorbent assay in relation with allograft outcome.
Results: Among 59 patients, 15 cases (25%) including 10 with acute rejection and 5 with chronic rejection episodes showed graft failure during a mean of 5 years of follow-up. High posttransplant levels of IgA anti-Fab antibodies were observed more frequently in patients with stable graft function (SGF) compared with patients with graft failure (P = 2 × 10(-6)). None of patients with acute or chronic rejection episodes had high levels of IgA anti-Fab antibodies at day 30 posttransplant compared with the SGF group (P = 10(-6) and P = .01, respectively). In addition, high levels of IgA anti-Fab antibody correlated with lesser concentration of serum creatinine at 1 month posttransplantation (P = .01). Five-year graft survival was associated with high levels of pre- and posttransplant IgA anti-Fab antibodies (P = .02 and P = .003, respectively).
Conclusions: Our findings indicate the protective effect of higher levels of IgA anti-Fab antibodies regarding to kidney allograft outcomes and long-term graft survival.
(Copyright © 2015 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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