Assessing the hierarchical structure of titanium implant surfaces.

Autor: Matteson JL; Department of Materials Science and Engineering, Pennsylvania State University, University Park, Pennsylvania, 16802., Greenspan DC; Spinode Consulting, St. Augustine, Florida, 32086., Tighe TB; Materials Research Institute, Pennsylvania State University, University Park, Pennsylvania, 16802., Gilfoy N; Zygo Corporation, Middlefield, Connecticut, 06455., Stapleton JJ; Materials Research Institute, Pennsylvania State University, University Park, Pennsylvania, 16802.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2016 Aug; Vol. 104 (6), pp. 1083-90. Date of Electronic Publication: 2015 May 29.
DOI: 10.1002/jbm.b.33462
Abstrakt: The physical texture of implant surfaces are known to be one important factor in creating a stable bone-implant interface. Simple roughness parameters (for e.g., Sa or Sz) are not entirely adequate when characterizing surfaces possessing hierarchical structure (macro, micro, and nano scales). The aim of this study was to develop an analytical approach to quantify hierarchical surface structure of implant surfaces possessing nearly identical simple roughness. Titanium alloys with macro/micro texture (MM) and macro/micro/nano texture (MMN) were chosen as model surfaces to be evaluated. There was no statistical difference (p > 0.05) in either Sa (13.56 vs. 13.43 µm) or Sz (91.74 vs. 92.39 µm) for the MM and MMN surfaces, respectively. However, when advanced filtering algorithms were applied to these datasets, a statistical difference in roughness was found between MM (Sa = 0.54 µm) and MMN (Sa = 1.06 µm; p < 0.05). Additionally, a method was developed to specifically quantify the density of surface features appearing similar in geometry to natural osteoclastic pits. This analysis revealed a significantly greater numbers of these features (i.e., valleys) on the MMN surface as compared to the MM surface. Finally, atomic force microscopy showed a rougher nano-texture on the MMN surface compared with the MM surface (p < 0.05). The results support recent published studies that show a combination of appropriate micron and nano surface results in a more robust cellular response and increased osteoblast differentiation. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1083-1090, 2016.
(© 2015 Wiley Periodicals, Inc.)
Databáze: MEDLINE
Externí odkaz: