Instructive Conductive 3D Silk Foam-Based Bone Tissue Scaffolds Enable Electrical Stimulation of Stem Cells for Enhanced Osteogenic Differentiation.

Autor: Hardy JG; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA. johnhardyuk@gmail.com.; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA. johnhardyuk@gmail.com.; Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA. johnhardyuk@gmail.com., Geissler SA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA.; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA., Aguilar D Jr; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA., Villancio-Wolter MK; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA., Mouser DJ; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA., Sukhavasi RC; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA., Cornelison RC; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA.; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA., Tien LW; Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA., Preda RC; Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA., Hayden RS; Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA., Chow JK; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA., Nguy L; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA., Kaplan DL; Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, 02155, USA. david.kaplan@tufts.edu., Schmidt CE; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, 32611, USA. schmidt@bme.ufl.edu.; Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 78712, USA. schmidt@bme.ufl.edu.
Jazyk: angličtina
Zdroj: Macromolecular bioscience [Macromol Biosci] 2015 Nov; Vol. 15 (11), pp. 1490-6. Date of Electronic Publication: 2015 Jun 01.
DOI: 10.1002/mabi.201500171
Abstrakt: Stimuli-responsive materials enabling the behavior of the cells that reside within them to be controlled are vital for the development of instructive tissue scaffolds for tissue engineering. Herein, we describe the preparation of conductive silk foam-based bone tissue scaffolds that enable the electrical stimulation of human mesenchymal stem cells (HMSCs) to enhance their differentiation toward osteogenic outcomes.
(© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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