Antioxidant Defense System after Single and Chronic Administration of Obestatin and Its Fragment (1-4) to Normal and Overweight Male Rats.

Autor: Khirazova EE; Department of Human and Animal Physiology, M. V. Lomonosov State Moscow University, Moscow, Russia, ekhirazova@gmail.com., Bayzhumanov AA, Motorykina ES, Devyatov AA, Maslova MV, Graf AV, Sokolova NA, Golubeva MG, Kamenskii AA
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2015 May; Vol. 159 (1), pp. 38-40. Date of Electronic Publication: 2015 Jun 02.
DOI: 10.1007/s10517-015-2884-y
Abstrakt: We studied the effects of anorectic peptide obestatin and its fragment (1-4) on the antioxidant defense system in animals with normal and experimentally induced increased body weight. In rats with normal body weight, no changes in activity of the antioxidant defense system 1 week after single administration of the substances. After chronic administration of obestatin and fragment (1-4) for 1 week, total antioxidant capacity of the plasma decreased; obestatin also lowered the content of TBA-reactive products. In the overweight rats, SOD-like activity in the plasma increased 1 week after chronic administration of obestatin. Hence, obestatin and its fragment (1-4) induced changes in the antioxidant defense system only after chronic administration.
Databáze: MEDLINE
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