Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity.

Autor: Gancarz AM; Department of Pharmacology and Toxicology, Research Institute on Addictions, Program in Neuroscience, State University of New York at Buffalo, Buffalo, New York, USA., Wang ZJ; Department of Pharmacology and Toxicology, Research Institute on Addictions, Program in Neuroscience, State University of New York at Buffalo, Buffalo, New York, USA., Schroeder GL; Department of Pharmacology and Toxicology, Research Institute on Addictions, Program in Neuroscience, State University of New York at Buffalo, Buffalo, New York, USA., Damez-Werno D; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Braunscheidel KM; Department of Pharmacology and Toxicology, Research Institute on Addictions, Program in Neuroscience, State University of New York at Buffalo, Buffalo, New York, USA., Mueller LE; Department of Pharmacology and Toxicology, Research Institute on Addictions, Program in Neuroscience, State University of New York at Buffalo, Buffalo, New York, USA., Humby MS; Department of Pharmacology and Toxicology, Research Institute on Addictions, Program in Neuroscience, State University of New York at Buffalo, Buffalo, New York, USA., Caccamise A; Department of Pharmacology and Toxicology, Research Institute on Addictions, Program in Neuroscience, State University of New York at Buffalo, Buffalo, New York, USA., Martin JA; Department of Pharmacology and Toxicology, Research Institute on Addictions, Program in Neuroscience, State University of New York at Buffalo, Buffalo, New York, USA., Dietz KC; Department of Pharmacology and Toxicology, Research Institute on Addictions, Program in Neuroscience, State University of New York at Buffalo, Buffalo, New York, USA., Neve RL; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Dietz DM; Department of Pharmacology and Toxicology, Research Institute on Addictions, Program in Neuroscience, State University of New York at Buffalo, Buffalo, New York, USA.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2015 Jul; Vol. 18 (7), pp. 959-61. Date of Electronic Publication: 2015 Jun 01.
DOI: 10.1038/nn.4036
Abstrakt: Activin receptor signaling, including the transcription factor Smad3, was upregulated in the rat nucleus accumbens (NAc) shell following withdrawal from cocaine. Direct genetic and pharmacological manipulations of this pathway bidirectionally altered cocaine seeking while governing morphological plasticity in NAc neurons. Thus, Activin/Smad3 signaling is induced following withdrawal from cocaine, and such regulation may be a key molecular mechanism underlying behavioral and cellular plasticity in the brain following cocaine self-administration.
Databáze: MEDLINE