Splenectomy attenuates obesity and decreases insulin hypersecretion in hypothalamic obese rats.

Autor: Leite Nde C; Department of Structural and Functional Biology, Institute of Biology, UNICAMP, Campinas, São Paulo, Brazil. Electronic address: nayaracleite@gmail.com., Montes EG; Department of General Biology, State University of Ponta Grossa, Ponta Grossa, Parana, Brazil., Fisher SV; Department of General Biology, State University of Ponta Grossa, Ponta Grossa, Parana, Brazil., Cancian CR; Department of General Biology, State University of Ponta Grossa, Ponta Grossa, Parana, Brazil., de Oliveira JC; Department of Biotechnology, Genetics and Cell Biology, State University of Maringa, Maringa, Parana, Brazil., Martins-Pinge MC; Departament of Physiological Sciences, State University of Londrina, Parana, Brazil., Kanunfre CC; Department of General Biology, State University of Ponta Grossa, Ponta Grossa, Parana, Brazil., Souza KL; Institute of Biophysics Carlos Chagas Filho (IBCCF/Polo Xerém), Federal University of Rio de Janeiro, UFRJ, Rio de Janeiro, Brazil., Grassiolli S; Department of General Biology, State University of Ponta Grossa, Ponta Grossa, Parana, Brazil.
Jazyk: angličtina
Zdroj: Metabolism: clinical and experimental [Metabolism] 2015 Sep; Vol. 64 (9), pp. 1122-33. Date of Electronic Publication: 2015 May 07.
DOI: 10.1016/j.metabol.2015.05.003
Abstrakt: Objective: Obesity-induced abnormalities, such as insulin resistance, dyslipidemia and hypertension, are frequently correlated with low-grade inflammation, a process that may depend on normal spleen function. This study investigated the role of the spleen in the obesity induced by monosodium glutamate (MSG) treatment.
Materials/methods: MSG-obese and lean control (CON) rats were subjected to splenectomy (SPL) or non-operated (NO).
Results: MSG-NO rats presented a high adipose tissue content, insulin resistance, dyslipidemia and islet hypersecretion, accompanied by hypertrophy of both pancreatic islets and adipocytes when compared with CON-NO rats. In addition, changes in nitric oxide response were found in islets from the MSG-NO group without associated alterations in inducible nitric oxide synthase (iNOS) or IL1β expression. MSG-NO also presented increased leukocyte counts and augmented LPS-induced nitric oxide production in macrophages. Splenectomy of MSG-obese animals decreased insulin hypersecretion, normalized the nitric oxide response in the pancreatic islets, improved insulin sensitivity and reduced hypertrophy of both adipocytes and islets, when compared with MSG-NO rats.
Conclusion: Results show that splenectomy attenuates the progression of the obesity modulating pancreas functions in MSG-obese rats.
(Copyright © 2015 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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